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Diss Factsheets
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EC number: 201-185-2 | CAS number: 79-20-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to other aquatic organisms
Administrative data
- Endpoint:
- toxicity to other aquatic vertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted standards.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- Methyl acetate
- EC Number:
- 201-185-2
- EC Name:
- Methyl acetate
- Cas Number:
- 79-20-9
- Molecular formula:
- C3H6O2
- IUPAC Name:
- methyl acetate
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- no
Test organisms
- Test organisms (species):
- Rana pipiens
- Details on test organisms:
- TEST ORGANISM
- Common name: Northern Leopard Frog
- Source: Commercial supplier
- Age at study initiation: Tadpoles
- Length at study initiation: Between 2.5 and 3.5 inches, corresponding to 6.4 and 8.9 cm
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Remarks on exposure duration:
- not reported
Test conditions
- Test temperature:
- 20°C
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass aquaria filled with 500 ml tap water containing various concentrations of the test substance
- No. of organisms per vessel: 10
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Tap water. No details on further preparation reported
EFFECT PARAMETERS MEASURED : Narcosis - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Dose descriptor:
- other: Threshold narcotic concentration defined as that concentration at which touching the tadpoles failed to cause motion
- Effect conc.:
- 157 mmol/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: test result
- Dose descriptor:
- other: Threshold narcotic concentration defined as that concentration at which touching the tadpoles failed to cause motion
- Effect conc.:
- 11 630.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: test result
- Dose descriptor:
- other: Threshold narcotic concentration defined as that concentration at which touching the tadpoles failed to cause motion
- Effect conc.:
- >= 70 - <= 90 mmol/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Data from Overton (1901) as cited in the publication converted to mg/L
- Dose descriptor:
- other: Threshold narcotic concentration defined as that concentration at which touching the tadpoles failed to cause motion
- Effect conc.:
- >= 5 185.6 - <= 6 667.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Data from Overton (1901) as cited in the publication, converted to mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Executive summary:
The narcotic potency of methyl acetate to tadpoles of Rana pipiens was assessed in a static system. Tadpoles were exposed to various concentrations of the substance and the threshold narcotic concentration was determined as the respective concentration at which tadpoles failed to cause motion. For methyl acetate this value was determined to be 157 mmol/l corresponsing to 11630.6 mg/l.
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