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EC number: 266-946-3 | CAS number: 67701-28-4 This substance is identified by SDA Substance Name: C8-C18 and C18 unsaturated trialkyl glyceride and SDA Reporting Number: 01-001-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Oct. 19, 2009 to Nov. 11, 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted according to standard guidelines (with GLP)
- Justification for data waiving:
- other:
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 850.6800 (Modified Activated Sludge, Respiration Inhibition Test for Sparingly Soluble Chemicals)
- Deviations:
- no
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Glycerides, C8-18 and C18-unsatd.
- EC Number:
- 266-946-3
- EC Name:
- Glycerides, C8-18 and C18-unsatd.
- Cas Number:
- 67701-28-4
- Molecular formula:
- Triglycerides containing a glycerol backbone esterified to fatty acids with a carbon chain length of C8-18 as well as unsaturated C18 fatty acids
- IUPAC Name:
- Tri(C8-18 and C18-unsatd. fatty acyl)glycerol
- Details on test material:
- - Name of test material (as cited in study report): Fully hydrogenated coconut oil (CAS N° 84836-98-6, EC N° 284-283-8); under the SDA nomenclature, the name of this substance is ‘Glycerides, C8-18 and C18-unsatd.’
- Physical state: Solid (bright yellow)
- Expiration date of the lot/batch: December 26, 2009
- Storage condition of test material: In original container, at room temperature (10-30 °C), in the dark
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- Not applicable
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: The test item was directly dosed into each test flask and tap water was added. The mixture was stirred for about 24h at 22 °C in the dark / diffuse light.
- Eluate: Water
- Controls: 2 controls (tap water, synthetic sewage and inoculum)
Test organisms
- Test organisms (species):
- activated sludge, domestic
- Details on inoculum:
- - Preparation of inoculum for exposure: Washed by centrifugation and the supernatant liquid phase was decanted. The solid material was suspended in tap water and again centrifuged (the procedure was repeated 3 times). The washed sludge was re-suspended in tap-water and sewage feed (50 mL/L) was added. The sludge was kept at room temperature under continouse aeration until use overnight. The suspension was fed again on the first d.
- Initial biomass concentration: 3.8 g/L
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Remarks on exposure duration:
- None
Test conditions
- Test temperature:
- 22 °C during dissolution phase
21 - 22 °C during pre-incubation
18 - 20 °C during evaluation period - pH:
- 7.4 - 8.4
- Dissolved oxygen:
- 2.5 - 7.9 mg O2/L
- Nominal and measured concentrations:
- 10, 32, 100, 320 and 1000 mg/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Flasks and Karlsruher flasks
- Type (delete if not applicable): Closed
- Material, size, headspace, fill volume: Glass, 1L volume and 250 mL volume (Karlsruher flasks)
- Aeration: Compressed air (0.8 L/min)
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 2
- Biomass loading rate: 0.76 g/L
OTHER TEST CONDITIONS
- Adjustment of pH: No
EFFECT PARAMETERS MEASURED: Oxygen consumption, measured after 3h of incubation time
TEST CONCENTRATIONS
- Test concentrations: 10, 32, 100, 320 and 1000 mg/L (nominal) - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dicholphenol
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: None
- Duration:
- 3 h
- Dose descriptor:
- other: EC20
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: None
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: None
- Details on results:
- - Based on measured inhibition rates, the 3h EC10, EC30 and EC50 could not be quantified because, up to the highest nonminal test concentration (1,000 mg/L), less than 10% inhibition was noted.
- The maximum deviation in respiration rates was 8% at a concentration of 100 mg/L, however, no inhibition was found at a concentration of 1000 mg/L. - Results with reference substance (positive control):
- - Results with reference substance valid: Yes
- Relevant effect levels: The 3h EC50 was calculated to be 15.2 mg/L (dues to mathematical reasons, no 95% CL could be determined - Reported statistics and error estimates:
- None
Any other information on results incl. tables
For more detailed information on the results, see table 1 and figure 1 in the window 'attached background material'.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the test condition, no dose related response was found in the activated sludge inhibition test with fully hydrogenated coconut oil. The 3h EC10, EC20 and EC50 were determined to be >1,000 mg/L (nominal).
- Executive summary:
The influence of fully hydrogenated coconut oil on the activity of the activated sludge was evaluated by measuring the respiration rate under defined conditions. The test followed the guidelines OECD 209, EU method C.11 and EPA OPPTS 850.6800 with GLP compliance.
The respiration rate (oxygen consumption) of an aerobic activated sludge fed with a standard amount of synthetic sewage was measured in the presence of variouse concentrations after an incubation period of 3h.
Three tests, one with a reference susbstance 3,5 -Dichlorophenol and two inoculum controls were run in parallel for validation purposes.
Under the test condition, no dose related response was found in the activated sludge inhibition test with fully hydrogenated coconut oil. The 3h EC10, EC20 and EC50 were determined to be >1,000 mg/L (nominal).
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