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EC number: 204-127-4 | CAS number: 116-15-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Four groups each of 25 male and 25 female Crl:CD-1(ICR)BR mice were exposed to target concentrations of 0, 10, 50 or 150 ppm hexafluoropropene (HFP) for 6 hours/day, 5 days/week for a period of approximately 90 days. Mean body weights and body weight gains for male and female mice were unremarkable and not affected by exposures to the test material. No differences in food consumption were noted for male or female mice during the study. Elevated levels of water consumption were observed in mice exposed to 150 ppm; these differences were statistically significant for female mice. Statistically significant observations of blue skin color to the abdomen were observed in male mice exposed to 50 or 150 ppm. The relationship of this observation to the test material is not clear. Hematology conducted in mice showed no effects that were related to HFP exposures. The notable effects in mice were the microscopic lesions observed in the kidneys of mice exposed to 50 of 150 ppm. The kidney lesions included regeneration of the inner cortical tubules, cytomegaly of tubular epithelium, and tubular epithelial necrosis.The No Observed Adverse Effect Level (NOAEL) for 90 days of repeated inhalation exposure to HFP in mice is 10 ppm. The NOAEL following 28 days of recovery is also 10 ppm. At recovery, cytomegaly and kidney nephropathy were present in male mice.
Rats were less sensitive to HFP related health effects than mice. Four groups each of 20 male and 20 female Crl:CDBR rats were exposed to target concentrations of 0, 10, 50 or 150 ppm HFP for 6 hours/day, 5 days/week for a period of approximately 90 days. Low mean lymphocyte count was observed in males exposed to 150 ppm. This effect was not observed following 28 days of recovery. There was no hematology or pathology support to consider the single observation of reduced mean lymphocyte count as adverse. Other non-adverse or non-biologically significant effects were observed in the 50 and 150 ppm exposure groups. These included increased levels of fluoride in the urine, increased urine volume, decreased urine osmolality and increased water consumption and elevated levels of serum sodium in the male groups exposed to 50 or 150 ppm.
The following information is taken into account for any hazard/risk assessment:
NOAEL = 61.4 mg/m3 (10 ppm)
Value used for CSA (route: inhalation):
NOAEL: 61.4 mg/m³ (10 ppm)
Justification for classification or non-classification
Based on the results of repeated inhalation studies, the substance is classified as Specific Target Organ Toxicity Repeated Exposure Category 2 (Kidney) according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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