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Diss Factsheets
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EC number: 235-715-9 | CAS number: 12607-70-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Nickel carbonate hydroxide is classified according to Annex I to Directive 67/548/EEC with Xn; R 20/22
Key value for chemical safety assessment
Additional information
Oral:
There is one acute oral LD50 study for nickel carbonate which gives values of 625 mg Ni/kg for male rats and 402 mg Ni/kg for female rats (approximately 1263 and 812 mg nickel carbonate/kg). Based on the measured value, classification of nickel carbonate hydroxide as Xn; R22 (GHS: Acute Tox. 4) is justified. This reflects the differences in water solubility of the carbonate (mg/l) compared to the soluble nickel salts (>100 g/l) (EU C&L Dossier and the OECD SIDS draft 2007).
Inhalation:
There is no data available for the acute inhalation toxicity of nickel carbonate and -hydroxide.Absorption of soluble nickel salts following inhalation is considerably greater than after oral
administration. The absorption of less soluble salts is less. A value of 100% absorption has
been agreed for the risk assessment, based on the Industry derogation statement to a “worst case”
comparison. Based on the proposal to classify the substance for acute oral toxicity,
classification for acute inhalational toxicity (R-20) is considered appropriate (GHS: Acute Tox. 4) (EU C&L Dossier and the OECD SIDS draft 2007).
Dermal:
There is no data available for the acute dermal toxicity of nickel carbonate and -hydroxide. In the view of the poor absorption by this route acute toxicity is expected to be low (EU C&L Dossier and the OECD SIDS draft 2007).
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.