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EC number: 203-005-8 | CAS number: 102-09-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- 6 to 7 samples are taken during the preliminary experiment at pH 4 and 7 and 50°C. At pH 9 only 4 analytical determinations are performed, due to fast degradation at 50°C. In the higher tier experiment 3 and 4 determinations were done at pH 4 and 7 at 30°C, respectively.
- Buffers:
- pH 4: citric acid/potassium hydroxide/sodium chloride
pH 7: potassium dihydrogen phosphate/Di-sodium hydrogen phosphate
pH 9: borax/hydrochlorid acid - Duration:
- 7 h
- pH:
- 4
- Temp.:
- 50 °C
- Duration:
- 4.5 h
- pH:
- 7
- Temp.:
- 50 °C
- Duration:
- 0.5 h
- pH:
- 9
- Temp.:
- 50 °C
- Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- 61.8 h
- Remarks on result:
- other: calculated
- pH:
- 4
- Temp.:
- 30 °C
- DT50:
- 40.2 h
- pH:
- 4
- Temp.:
- 50 °C
- DT50:
- 8.2 h
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 39.9 h
- Remarks on result:
- other: calculated
- pH:
- 7
- Temp.:
- 30 °C
- DT50:
- 24.1 h
- pH:
- 7
- Temp.:
- 50 °C
- DT50:
- 3.8 h
- pH:
- 9
- Temp.:
- 50 °C
- DT50:
- 0.2 h
- Conclusions:
- Diphenyl carbonate hydrolyses under environmental conditions forming phenol and carbon dioxide. Environmental relevant half-life is 39.9 h at pH 7 and 25 °C.
- Executive summary:
The stability of diphenyl carbonate was examined in accordance with the standardised guideline EU Method C.7 under GLP conditions.
The guideline is designed as a tiered approach. Firstly, a preliminary experiment was carried out in different buffer solutions at pH 4, 7 and 9 at 50 °C. Hydrolysis was followed by measuring the increase of the concentration of the hydrolysis product phenol with time, using HPLC. As the results of the preliminary test indicated that less than 50 % of diphenyl carbonate had hydrolysed in 2.4 hours at pH 4 and 7 at 50 °C, further testing was required. Based on the conclusion that degradation is a pseudo-first order reaction, the secondary experiment was carried out only at pH 4 and 7 at 30 °C. No further testing was required at pH 9 since more than 50 % of diphenyl carbonate had hydrolysed in 2.4 hours at 50 °C and pH 9.
Based on the results at 50 and 30 °C an environmentally relevant half-life time was estimated using the Arrhenius equation of a first-order reaction.
Diphenyl carbonate hydrolyses under environmental conditions, forming phenol and carbon dioxide. Environmentally relevant half-life is 39.9 h at pH 7 and 25 °C.
Reference
- At pH 9 and 50°C fast degradation was observed. Within
ca. 40 minutes the concentration of diphenyl carbonate
decreased to less than 7 %. During this time just 4
analytical determinations were possible. Assuming a
pseudo-first order reaction a half-life of 0.15 hours at pH 9
was calculated
- At pH 7 and pH 4 degradation was followed at 30 and 50°C
- According to the Arrhenius equation the half-life and the rate constant (first order reaction) at 25°C was calculated.
Description of key information
Diphenyl carbonate hydrolyses under environmental conditions forming phenol and carbon dioxide. Environmentally relevant half-life is 39.9 h at pH 7 and 25 °C, EU Method C.7 (Bayer, 2001a).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 39.9 h
- at the temperature of:
- 25 °C
Additional information
In the key study, the stability of diphenyl carbonate was examined in accordance with the standardised guideline EU Method C.7 under GLP conditions (Bayer, 2001a). The study was awarded a reliability score of 1 in accordance with the criteria for assessing data quality as set forth by Klimisch et al. (1997).
The guideline is designed as a tiered approach. Firstly, a preliminary experiment was carried out in different buffer solutions at pH 4, 7 and 9 at 50 °C. Hydrolysis was followed by measuring the increase of the concentration of the hydrolysis product phenol with time, using HPLC. As the results of the preliminary test indicated that less than 50 % of diphenyl carbonate had hydrolysed in 2.4 hours at pH 4 and 7 at 50 °C, further testing was required. Based on the conclusion that degradation is a pseudo-first order reaction, the secondary experiment was carried out only at pH 4 and 7 at 30 °C. No further testing was required at pH 9 since more than 50 % of diphenyl carbonate had hydrolysed in 2.4 hours at 50 °C and pH 9.
Based on the results at 50 and 30 °C an environmentally relevant half-life time was estimated using the Arrhenius equation of a first-order reaction.
Diphenyl carbonate hydrolyses under environmental conditions, forming phenol and carbon dioxide. Environmentally relevant half-life is 39.9 h at pH 7 and 25 °C.
Further information is available in the form of a supporting study in which the degradation kinetic was determined in accordance with generally accepted scientific principles (Bayer, 2000a). The study was awarded a reliability score of 2 in accordance with the criteria for assessing data quality as set forth by Klimisch et al. (1997).
A saturated solution of diphenyl carbonate in water was stirred at room temperature (23 °C) for 48 h. Following centrifugation, the phases were separated. The concentration of the test material was regularly determined by HPLC.
Diphenyl carbonate hydrolyses in water, forming phenol and carbon dioxide. The half-life is indicated to be 73.5 h at 23 ° C.
Stability of the hydrolysis product phenol was assessed in a European Union Risk Assessment Report(European Chemicals Bureau, 2006). Phenol is hydrolytically stable.
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