Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-469-4 | CAS number: 121-44-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Similar to guideline study; not GLP
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Subchronic inhalation of triethylamine vapor in Fisher-344 rats: organ system toxicity
- Author:
- Lynch et al.
- Year:
- 1 990
- Bibliographic source:
- Toxicol Ind Health 6(3/4): 403-414.
- Reference Type:
- other: report
- Title:
- Narrative summary of histomorphological findings from F344 rats exposed by inhalation to allylamine (4 and 40 ppm) and triethylamine (25 and 250ppm) for 30, 60 and 120 days
- Author:
- no author
- Year:
- 1 984
- Bibliographic source:
- NIOSH
- Reference Type:
- other: USEPA TSCA 8(d) submission
- Title:
- untitled
- Author:
- no author
- Year:
- 1 987
- Bibliographic source:
- TSCATS, OTS 0515254, Doc.I.D. 86-870000816, Virginia Chemicals
- Report date:
- 1987
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 413 (Subchronic Inhalation Toxicity: 90-Day Study)
- Deviations:
- yes
- Remarks:
- two dose levels were used
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 452 (Chronic Toxicity Studies)
- Deviations:
- yes
- Remarks:
- two dose levels were used
- Principles of method if other than guideline:
- In the present study only two dose levels were used in addition to the concurrent control group. The duration of the study is 28 weeks. Not all examinations are performed.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Triethylamine
- EC Number:
- 204-469-4
- EC Name:
- Triethylamine
- Cas Number:
- 121-44-8
- Molecular formula:
- C6H15N
- IUPAC Name:
- triethylamine
- Details on test material:
- CAS 121-44-8 (triethylamine), purity >99.9% was obtained from MCB Manufacturing Chemists, Inc., Norwood, OH
Lot number G3M04
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Strain:Weanling caesarean-derived Fisher F344 [CDF (F-344)/Crl BR]
Rats were screened for serological evidence of Mycoplasma pulmonis infection prior to the initiation of exposures and all results were negative.
- Source: Charles River breeding Laboratories, Wilmington MA
- Age at study initiation: not reported
- Weight at study initiation: not reported
- Fasting period before study: no
- Housing: individually
- Diet (e.g. ad libitum): except during the exposure periods.
- Water (e.g. ad libitum): except during the exposure periods.
- Acclimation period: 2 weeks
ENVIRONMENTAL CONDITIONS
- Air changes (per hr): 12-15/hour
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- whole body
- Vehicle:
- not specified
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Exposures were conducted in three 4.5 m³ stainless steel and glass inhalation chambers (Hinners et al., 1968) operated under dynamic flow conditions.
- Temperature, humidity in air chamber: 23 ± 3°C and 50 ± 10% RH, respectively.
- Air flow rate: 12-15 air changes per hr
- Treatment of exhaust air: A fresh batch of TEA was used in the generation reservoir each day.
TEST ATMOSPHERE
- Brief description of analytical method used: Wilks-Miran 1A Infrared Analyzer (Foxboro Analytical, Norwalk, CT) using the following instrument settings: wavelength 9 µm, pathlength 6.2 m, slit 1.0 mm. The instrument was calibrated by the closed loop calibration method. Adjustments were made to the generation system, as required, to maintain the exposure levels at the targeted concentrations.
- Samples taken from breathing zone: yes. TEA concentrations in the chamber were monitored 2-4 times per hour using a Wilks-Miran 1A Infrared Analyzer (Foxboro Analytical, Norwalk, CT)
VEHICLE (if applicable) no - Analytical verification of doses or concentrations:
- yes
- Details on analytical verification of doses or concentrations:
- 2-4 times/hour with a Wilks-Miran Infrared Analyzer
- Duration of treatment / exposure:
- 28 weeks
- Frequency of treatment:
- 6 hours/day, 5 days/week
127 maximum exposure days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 25 and 247 ppm (0, 103 and 1020 mg/m3)
Basis:
nominal conc.
- No. of animals per sex per dose:
- 50/sex/dose
- Control animals:
- yes
- Details on study design:
- - Dose selection rationale: Exposure concentrations were selected to provide comparisons to previous toxicity determinations conducted in this laboratory with diethylamine at 25 and 250 ppm (Lynch et al., 1986).
- Rationale for animal assignment (if not random): randomised - Positive control:
- no
Examinations
- Observations and examinations performed and frequency:
- Mortality/clinical signs: twice daily
Body weight: 2-weekly - Sacrifice and pathology:
- 10/sex/treatment sacrificed after ~30 and ~60 days of exposure, 20 after ~ 125 days of exposure (10 in controls)
Hematology: at each scheduled sacrifice: Hb, hematocrit, red blood cells, white blood cells (total and differential count)
Clinical chemistry: at each scheduled sacrifice: ALAT, ASAT, creatine phosphokinase, blood urea nitrogen, creatinine, LDH, sorbitol dehydrogenase. EGC at terminal sacrifice in 9-11 rats/sex/treatment
Necropsy Organ weights: lungs, liver, kidneys and heart
Macroscopic evaluation: complete
Histopathology: lungs, liver, heart, spleen, kidneys, tracheobronchial lymphnodes, adrenals, urinary bladder, testes, seminal vesicles, uterus, ovaries, trachea, eyes, nasal passages (according to Buckley, 1985) - Statistics:
- t-test, multivariate analysis of variance, Kruskal-Wallis and chi-square test
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Clinical biochemistry findings:
- effects observed, treatment-related
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Organ weight findings including organ / body weight ratios:
- no effects observed
- Gross pathological findings:
- no effects observed
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- effects observed, treatment-related
- Details on results:
- Mean chamber concentrations: 0, 24.8 and 247.3 ppm
Observations: Mortality: 1 female at 25 ppm (week 6), 1 male(week 8) and 2 females (week 3)(both accidentally) at 247 ppm
Clinical signs: at 247 ppm closed eyes and noses buried in fur Body weight gain: slightly reduced in males (dose-related)
Hematology: no treatment related effects
Clinical chemistry: incidentally increases of ALAT, creatinine and sorbitol dehydrogenase. EGC within normal ranges
Macroscopy: no treatment related effects
Histopathology: Chronic inflammation of the lungs in all treated and control animals after 30 and 125 exposures. Male lung weights were increased in a concentration-dependent manner, although the changes were not statistically significant or accompanied by any histopathology. Liver necrosis(focal) in all treated and control animals after 125 exposures. Minimal focal necrosis of myofibers of the heart in males at 25 ppm after 125 exposures
Neoplastic lesions: nephroblastoma in one female at 25 ppm after 30 exposures, pituitary adenoma in one male at 247 ppm after 125 exposures, thyroid follicular cell adenoma in one control female after 125 exposures
Effect levels
open allclose all
- Dose descriptor:
- NOAEC
- Remarks:
- systemic effects
- Effect level:
- 1 020 mg/m³ air
- Sex:
- male/female
- Basis for effect level:
- other: clinical signs
- Dose descriptor:
- NOAEC
- Remarks:
- local effects, irritation
- Effect level:
- 103.3 mg/m³ air
- Sex:
- male/female
- Basis for effect level:
- other: no effects
- Dose descriptor:
- LOAEC
- Remarks:
- eye and noses irritation
- Effect level:
- 1 020 mg/m³ air
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: irritation effects
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
1. Lung lesions were associated with viral infection according to the author of the report.
2. Neoplastic lesions were not associated with exposure to the test substance.
3. There was no cardic muscle degenerations
or any changes in electrocardiogramms.
Applicant's summary and conclusion
- Conclusions:
- Triethylamine do not induce systemic toxicity in rats if inhaled.
- Executive summary:
Male and female F-344 rats were exposed at 0, 25, or 247 ppm triethylamine (TEA) vapor, 6 hr per day, 5 days per week for up to 28 weeks in order to characterize the subchronic organ system toxicity. Rats were weighed biweekly and scheduled sacrifices were performed following about 30, 60, and 120 days of exposure. No statistically significant treatment-related effects on organ weights, hematology, clinical chemistry, or electrocardiographic indices were observed. Body weight gain was not affected by TEA treatment. No physiologic or pathologic evidence of cardiotoxicity was seen in rats exposed to either TEA concencentrations for up to 28 weeks. No gross or histopathological lesions attributable to TEA exposure were noted in any of the organs examined, including the nasal passages.
Based on the study results 25 ppm (corresponds to 103.3 mg/m³) is considered to be a NOAEC for local effects and irritation, while 247 ppm, the highest concentration tested (corresponds to 1020 mg/m³), repesents a NOAEC for systemic effects and simultaneously a LOAEC for eye and nose irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.