Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-570-6 | CAS number: 142-90-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- other: Thesis
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 428 (Skin Absorption: In Vitro Method)
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-Propenoic acid, 2-methyl-, C12-16-alkyl esters
- EC Number:
- 292-094-7
- EC Name:
- 2-Propenoic acid, 2-methyl-, C12-16-alkyl esters
- Cas Number:
- 90551-76-1
- IUPAC Name:
- 2-Propenoic acid, 2-methyl-, C12-16-alkyl esters
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Lauryl methacrylate
- Supplier: Röhm GmbH - Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 48 hrs
- Doses:
- 100 µl / cm²
- Details on study design:
- The absorption of Lauryl methacrylate was evaluated through rat epidermis and intact skin in an in vitro system. Values for human skin absorption
were extrapolated on the basis of a 14 times more efficient permeation through rat skin obtained in an epidermal PBPK model developed in this study.
Results and discussion
- Signs and symptoms of toxicity:
- not examined
- Dermal irritation:
- not examined
- Absorption in different matrices:
- Absorption of Lauryl methacrylate through rat epidermis:
The substance is readily absorbed through rat epidermis at a constant mean rate of 26.2 µg cm-2 hr-1.
This rate of absorption is virtually constant over the duration of the experiment.
The total amount of chemical that was absorbed during the time of exposure was 0.7 % of the applied dose.
Absorption of Lauryl methacrylate through whole rat skin:
Like the smaller esters investigated, Lauryl methacrylate was also metabolised to methacrylic acid as it was absorbed through whole rat skin. The peak rate of appearance of methacrylic acid was calculated to be 11.8 µg cm-2 hr-1, which occurred between 8 and 24 hours.
0.264 % of the Lauryl methacrylate was depleted from the donor reservoir over the 24 hr exposure period.
Percutaneous absorptionopen allclose all
- Dose:
- 100 µl/cm²
- Parameter:
- percentage
- Absorption:
- 0.7 %
- Remarks on result:
- other: 24 hrs
- Remarks:
- Rat epidermis
- Parameter:
- percentage
- Absorption:
- 0.264 %
- Remarks on result:
- other: 24 hrs
- Remarks:
- whole rat skin
- Conversion factor human vs. animal skin:
- With respect to human skin, 14 times more efficient permeation through rat skin obtained in an epidermal PBPK model developed in this study.
Applicant's summary and conclusion
- Conclusions:
- Lauryl methacrylate is absorbed through rat skin to a low extent, 0.26 % within 24 hours.
The presence of carboxyl esterases in the skin completely hydrolyses the substance, only the resulting metabolite methacrylic acid was
demonstrated to pass through.
With respect to human skin, 14 times more efficient permeation through rat skin obtained in an epidermal PB-PK model developed in this study. - Executive summary:
The absorption of Lauryl methacrylate (LMA) was evaluated through whole rat skin and rat epidermis in an in vitro system.
The technique measures the rate of absorption of LMA across the rat skin and epidermis. Glass diffusion cells are employed to measure the amount of LMA that is received into a receptor chamber with respect to time, following the application of 100 µl/cm² of LMA to the epidermal surface. The mean rate of absorption was 26.2 µg cm-2 hr-1 for rat epidermis and 7.72 µg cm-2 hr-1 for whole rat skin.
The total amount of chemical that was absorbed during the time of exposure was 0.7 % (rat epidermis) and 0.26 % (rat whole skin) over 24 hours, respectively. LMA appears to be absorbed through rat skin and epidermis to a low extent As indicated by a PB-PK model used in this study, human skin is 14 times less permeable to LMA than rat skin.
NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)