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EC number: 201-180-5 | CAS number: 79-14-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not stated
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Well-documented double-blind vehicle-controlled clinical study; Not standard guideline, but uses good scienitific principles; No mention of GCP/GLP guidelines but subjects did sign an informed consent prior to study initiation; No analytical confirmation of test material reported
Data source
Reference
- Reference Type:
- publication
- Title:
- Clinical Improvement of Photoaged Skin with 50% Glycolic Acid
- Author:
- N. Newman, A. Newman, L.S. Moy, R. Babapour, A.G. Harris, R.L. Moy.
- Year:
- 1 996
- Bibliographic source:
- American Society for Dermatologic Surgery, 22: 455-460
Materials and methods
- Type of study / information:
- Clinical study for photoageing in human skin
- Endpoint addressed:
- not applicable
- Principles of method if other than guideline:
- The purpose of the study was to determine whether 50% glycolic acid can improve photoaged skin and to study the histological basis for improvement
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Glycollic acid
- EC Number:
- 201-180-5
- EC Name:
- Glycollic acid
- Cas Number:
- 79-14-1
- Molecular formula:
- C2H4O3
- IUPAC Name:
- 2-hydroxyacetic acid
- Details on test material:
- Glycolic acid 50%
Constituent 1
Method
- Details on study design:
- Forty-one volunteers were recruited into this doubleblind vehicle-controlled study. Glycolic acid (50%) or vehicle
was applied topically for 5 minutes to one side of the face, forearms, and hands, once weekly for 4 weeks. Punch biopsies
were taken at pretherapy and at 5 weeks for histologic study.
Results and discussion
- Results:
- Significant improvement noted included decrease in rough texture and fine wrinkling, fewer solar keratoses, and a
slight lightening of solar lentigines. Histology showed thinning of the stratum corneum, granular layer enhancement, and epidermal
thickening. Some specimens showed an increase in collagen thickness in the dermis.
Applicant's summary and conclusion
- Conclusions:
- The results of this study demonstrate that the application of 50% glycolic acid peels improves mild photoaging of the skin
- Executive summary:
The purpose of this study was to determine whether 50% glycolic acid can improve photoaged skin and to study the histological basis for this improvement. Forty-one volunteers were recruited into this doubleblind vehicle-controlled study. Glycolic acid (50%) or vehicle was applied topically for 5 minutes to one side of the face, forearms, and hands, once weekly for 4 weeks. Punch biopsies were taken at pretherapy and at 5 weeks for histologic study.
Significant improvement noted included decrease in rough texture and fine wrinkling, fewer solar keratoses, and a slight lightening of solar lentigines. Histology showed thinning of the stratum corneum, granular layer enhancement, and epidermal thickening. Some specimens showed an increase in collagen thickness in the dermis.
The results of this study demonstrate that the application of 50% glycolic acid peels improves mild photoaging of the skin.
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