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Diss Factsheets
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EC number: 200-712-3 | CAS number: 69-72-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- data not available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study which meets the basic scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Acute LD50 by intraperitoneal route
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Salicylic acid
- EC Number:
- 200-712-3
- EC Name:
- Salicylic acid
- Cas Number:
- 69-72-7
- Molecular formula:
- C7H6O3
- IUPAC Name:
- 2-hydroxybenzoic acid
- Details on test material:
- - Name of test material (as cited in study report): acide salicylique
- Substance type: pure active substance
- Stability under test conditions: data not available
- Storage condition of test material: data not available
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Charles River
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: # 20 g
- Source, Age at study initiation, Fasting period before study, Housing, Diet (e.g. ad libitum), Water, Acclimation period: data not available
ENVIRONMENTAL CONDITIONS
- Temperature, Humidity, Air changes, Photoperiod: data not available
IN-LIFE DATES: data not available
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- 420, 500, 600, 720, 865 mg/kg
- No. of animals per sex per dose:
- 6 male mice per group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 10 days
- Frequency of observations and weighing: data not available
- Necropsy of survivors performed: data not available - Statistics:
- data not available
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 575 mg/kg bw
- Remarks on result:
- other: substance left 3 months at 35°C and 90% relative humidity
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 620 mg/kg bw
- Remarks on result:
- other: fresh substance
- Mortality:
- Mortality was observed at 600, 720 and 865 mg/kg (see table)
- Clinical signs:
- data not available
- Body weight:
- data not available
- Gross pathology:
- data not available
- Other findings:
- The difference of LD50 between the two batch is not significant (Chi Square test)
Any other information on results incl. tables
Table 1: Mortality after 10 days
Dose level (mg/kg) |
Mortality after 10 days |
|
Salicylic acid left 3 months at 35°C et at 90% relative humidity |
Fresh salicylic acid |
|
420 |
0 / 6 |
0 / 6 |
500 |
0 / 6 |
0 / 6 |
600 |
4 / 6 |
3 / 6 |
720 |
6 / 6 |
5 / 6 |
865 |
6 / 6 |
6 / 6 |
Applicant's summary and conclusion
- Executive summary:
In an acute toxicity test, males Charles River mice (6 per dose) were intraperitoneally injected with salicylic acid at the dose levels of 420, 500, 600, 720 and 865 mg/kg bw. The mortality was reported after 10 days.
LD50 batch CA 80 253 73 03 (3 months at 35°C and 90% relative humidity): 575 mg/kg bw
LD50 batch CA 80 253 02 (fresh substance): 620 mg/kg bw
The difference between the two batches was not significant.
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