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EC number: 221-201-1 | CAS number: 3030-47-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Report on Assessment of Toxicokinetic Behaviour based on literature search and Estimation of Toxicokinetics based on the toxicological test results
- Adequacy of study:
- key study
- Study period:
- From November 2012 to March 2013
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific method and is described in sufficient detail.
Data source
Reference
- Reference Type:
- other: Assessment report from available information
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Objective of study:
- other: Finding of all available infomation about absorption, distribution, elimination, event. metabolism of the substance and estimation of the substance fate in organism
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Evaluation of toxicokinetics of the substance Pentamethyldiethylentriamine was performed according to the demand given in part 8.8.1 of Annex VIII to the Directive (EC) No. 1907/2006 (REACH) : “Assessment of the toxicokinetic behaviour of the substance to the extent that could be derived from the relevant available information”.
Toxicokinetics of the substance was evaluated from the following sources:
- Literature data obtained from commercial and free databases and from internet data.
- Experimental data of toxicological tests (unpublished).
Literature search was performed using the selected databases from STN International (Scientific and Technical Information Network) database service containing the data about physico-chemical, ecotoxicological, medical and toxicological properties of the substances.
The results of experimental studies were used for the assessment of toxicokinetic behaviour of the test substance.
Test material
- Reference substance name:
- Bis(2-dimethylaminoethyl)(methyl)amine
- EC Number:
- 221-201-1
- EC Name:
- Bis(2-dimethylaminoethyl)(methyl)amine
- Cas Number:
- 3030-47-5
- Molecular formula:
- C9H23N3
- IUPAC Name:
- (2-{[2-(dimethylamino)ethyl](methyl)amino}ethyl)dimethylamine
- Reference substance name:
- bis(2-dimethylamino)(methyl)amine
- IUPAC Name:
- bis(2-dimethylamino)(methyl)amine
- Reference substance name:
- Polykat 5
- IUPAC Name:
- Polykat 5
Constituent 1
Constituent 2
Constituent 3
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): bioaccumulation potential cannot be judged based on study results
The toxicity of the substance after acute exposure is generally low. The test substance after single oral administration of high dose level invoked the following toxic effects in the testing organism: death of animals, and clinical and pathological findings. The test substance penetrated into organism after single oral application – the systemic toxicity was observed.
After acute dermal exposure, the local changes of the test area (irritation, necrosis) were irreversible. The substance is corrosive for skin. No systemic toxicity was observed, so the substance did not enter the organism through the skin.
After acute eye exposure the substance causes irreversible local effects on the eye of the test animals. No systemic effects were reported.
Following acute inhalation exposure, no systemic toxicity was reported, so this way of entry to the organism is also not relevant.
Repeated whole-body exposure of rats to the vapor of the test substance caused extensive irritation of the upper respiratory tract, skin and eyes. The changes observed were indicative of nonselective localized irritation to tissues by exposure to the test material. Only local effects were observed, no systemic toxicity.
Repeated oral dose exposure to the test substance resulted in absorption into organism and subsequent systemic distribution. The main target organ was liver. After oral administration, the test substance caused systemic intoxication. It was relatively quickly absorbed from digestive tract and systemically distributed through the body (hours). It affected heart, liver, lungs, brain, etc. through blood circulation. With respect to reproduction toxicity part of the repeated dose study it was not possible to confirm penetration through the placental barrier.
No data about metabolism, distribution and excretion of the test substance were found. - Executive summary:
Executive summary:
Evaluation of toxicokinetics of the substance Pentamethyldiethylentriamine was performed according to the demand given in part 8.8.1 of Annex VIII to the Directive (EC) No. 1907/2006 (REACH) : “Assessment of the toxicokinetic behavior of the substance to the extent that could be derived from the relevant available information”.
Toxicokinetics of the substance was evaluated from following sources:
- Literature data obtained from commercial and free databases and from internet data.
- Experimental data of toxicological tests (unpublished).
Based on literature data, no concrete information about absorption, distribution, metabolism and excretion of the test substance was found.
The assessment of toxicokinetic behaviour of the substance, Pentamethyldiethylentriamine, was performed, based on the results of toxicological tests.
The test substance after single oral administration of high dose level invoked the following toxic effects in the tested organism: death of animals, and clinical and pathological findings. The test substance penetrated into organism after single oral application – the systemic toxicity was observed.
After acute dermal exposure, the local changes of test area (irritation, necrosis) were irreversible. The substance is corrosive for skin. No systemic toxicity was observed, so the substance did not enter the organism through the skin. After acute eye exposure, the substance caused irreversible local effects on eye of the test animals. No systemic effects were reported. In experiments with acute inhalation exposure, no systemic toxicity was reported, so this way of entry to the organism was not relevant also.
Repeated oral exposure of the substance resulted in entering into organism and its systemic distribution. The main target organ in organism was liver. After oral administration, the test substance caused systemic intoxication of organism. It was fairly quickly absorbed from digestive tract and systemically distributed through the body (hours). Through the blood circulation, it affected heart, liver, lungs, brain, etc.
Repeated whole-body exposure of rats to the vapor of the test substance caused extensive irritation of the upper respiratory tract, skin and eyes. The changes observed were indicative of nonselective localized irritation to tissues by exposure to the test material. Only local effects were observed, no systemic toxicity.
With respect to the results of reproduction toxicity part of repeated dose study it was not possible to confirm penetration through the placental barrier.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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