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EC number: 215-686-9 | CAS number: 1344-08-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 November 1985- 09 December 1985
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was not performed under GLP. OECD 404 was followed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Disodium tetrasulphide
- EC Number:
- 234-805-5
- EC Name:
- Disodium tetrasulphide
- Cas Number:
- 12034-39-8
- Molecular formula:
- Na2S4
- Details on test material:
- Chemical name: disodium tetrasulphide (natriumtetrasulfid)
Appearance: Yellow-brown solid
No CoA included in the study, no information on purity and composition of the test substance. For additional information see attached document.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: White Russen (albino)
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Asta-Werke AG, D-4800 Bielefeld 14
- Age at study initiation: 6 - 11 months
- Weight at study initiation: 2.2 - 2.5 kg
- Fasting period before study: Not applicable.
- Housing: steel cages, bar floor, model asta. One animal per cage.
- Diet (e.g. ad libitum): Ad libitum, standard food for rabbits, ssniff(K).
- Water (e.g. ad libitum): Ad libitum.
- Acclimation period: minimal 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 15
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: 25 November 1985- 09 December 1985
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: 2 sites are shaved and 2 sites are shaved and abraded
- Vehicle:
- water
- Controls:
- other: 2 sites with untreated skin are used a control sites
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 grams
- Concentration (if solution): the test substance was moistened with 0.15 ml water - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 14 days
- Number of animals:
- 3 males
- Details on study design:
- TEST SITE
On the back of the animals 4 sites were created. The whole area was shaved. 2 sites were also abraded. 1 shave and 1 abraded site was exposed to the test substance.
- Area of exposure: on the back of the animals between shoulder and hipbone.
- % coverage: 6.25 cm2
- Type of wrap if used: occlusive
REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: no data
SCORING SYSTEM: Draize (1944)
Erythema and eschar formation
0 No erythema
1 Very slight erythema (barely perceptible)
2 Well defined erythema
3 Moderate to severe erythema
4 Severe erythema (beet redness) to slight eschar formation (injuries in depth)
Oedema formation
0 No oedema
1 Very slight edema(barely perceptible)
2 Slight edema(edges of the area well defined by definite raising)
3 Moderate edema(raised approximately 1mm)
4 Severe edema( raised more than 1 mm and extending beyond the area of exposure)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- see remark on results
- Basis:
- other: see remark on results
- Time point:
- 24/48/72 h
- Score:
- > 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- see remark on results
- Remarks on result:
- other: Since corrosion was observed average scores were not calculated.
- Irritation parameter:
- edema score
- Remarks:
- see remark on results
- Basis:
- other: see remark on results
- Time point:
- 24/48/72 h
- Score:
- > 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- see remark on results
- Remarks on result:
- other: Since corrosion was observed average scores were not calculated.
- Irritant / corrosive response data:
- After removal of the patches the skin showed green to grey/black, shiny discoloration. The edges of the apllication area was discolored white.
Erythema was oberved 24 after the end of the application (in the results tabele it is already scored after 1 hours and given score 3 so this is not correct in the report). The redness was spread over the backs of the animals. Corrosion was observed, 2-4 millimeter deep corrison was observed. Scabs were observed after 14 days.
Oedema was seen immediatly after patch removal (score 3). In the second week the oedema had reversed.
See table 1. - Other effects:
- Systemic effects were not observed.
Any other information on results incl. tables
Table 1. Summary of dermal lesions (following 4-h application) on intact skin
no. |
Effect |
Hour |
Days after application |
Mean score erythema 24/48/72 h |
Mean score oedema 24/48/72 h |
|||||
1 |
1 |
2 |
3 |
7 |
14 |
|
|
|
||
1 |
Erythema/ eschar Oedema |
3
3 |
3
2 |
3
1 |
3
1 |
|
** |
|
*** |
*** |
2 |
Erythema/ eschar Oedema |
*
4 |
3
4 |
3
3 |
3
3 |
|
** |
|
*** |
*** |
3 |
Erythema/ eschar Oedema |
*
4 |
3
3 |
3
2 |
3
2 |
|
** |
|
*** |
*** |
Mean |
|
|
|
|
|
|
|
|
|
|
* due to severity of the effects skin could not be scored.
** after 14 days scabs were observed. Half way during the second week the oedema was reduced.
*** since the test substance has a corrosive effect on the skin the average scores were not calculated.
The untreated control skin showed no effects. Results of the abrade skin are not shown.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Corrosion was observed in all animals after a 4 hour exposure < 14 days. If corrosion would occur after 3 minutes or 1 hour exposure cannot be judged e.g category 1A or 1B is in place. The substance is classified by the EU in category 1B therfore that C&L is taken over here.
- Executive summary:
According to OECD404 a skin irritation study was performed in rabbits. 3 animals were used. On the back of the animals 4 sites were created. The whole area was shaved. 2 sites were also abraded. 1 shave and 1 abraded site was exposed to the test substance. the sites were exposed to 0.5 grams under occlusion. After removal of the patches the skin showed green to grey/black, shiny discoloration. The edges of the apllication area was discolored white.
Erythema was oberved 24 after the end of the application (in the results tabel it is already scored after 1 hours and given score 3 so this is not correct in the report). The redness was spread over the backs of the animals. Corrosion was observed, 2-4 millimeter deep corrison was observed. Scabs were observed after 14 days.
Oedema was seen immediatly after patch removal (score 3). In the second week the oedema had reversed.
Corrosion was observed in all animals after a 4 hour exposure < 14 days.
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