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Diss Factsheets
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EC number: 237-574-9 | CAS number: 13845-36-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See read-across justification report under Section 13 ‘Assessment Reports’.
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
In accordance with REACH Annex XI, Section 1.5, of Regulation (EC) No. 1907/2006 (REACH) the standard testing regime may be adapted in cases where a grouping or read-across approach has been applied.
The similarities may be based on:
(1) a common functional group
(2) the common precursors and/or the likelihood of common breakdown products via physical or biological processes, which result in structurally similar chemicals; or
(3) a constant pattern in the changing of the potency of the properties across the category
1. Both substances are inorganic salts of a monovalent cation from Group 1A of the periodic table, and triphosphoric acid. Thus, they share the Na+ or K+ cation and P3O105- anion.
2. Both substances will ultimately dissociate into the common breakdown products of the Na+ or K+ cations and the P3O105- anion, resulting in further breakdown products of pyrophosphate and orthophosphate anions.
3. Sodium and potassium cations are ubiquitous in natural waters and are considered to possess similar toxicological and ecotoxicological profiles due in part to their similar behaviour and their existence as essential micronutrients. The triphosphate anion in both substances will breakdown in the environment via the processes of hydrolysis, biotic degradation and assimilation by organisms in the environment, resulting in the breakdown products of pyrophosphate and orthophosphate anions. Ultimately, pyrophosphate anions will also breakdown to orthophosphate. It is therefore considered to be scientifically unjustified to conduct further testing on pentapotassium triphosphate as the read across can be adequately justified.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
See read-across justification report under Section 13 ‘Assessment Reports’.
3. ANALOGUE APPROACH JUSTIFICATION
See read-across justification report under Section 13 ‘Assessment Reports’.
4. DATA MATRIX
See read-across justification report under Section 13 ‘Assessment Reports’. - Reason / purpose for cross-reference:
- read-across: supporting information
- Qualifier:
- according to guideline
- Guideline:
- other: French standard NF T90-303 (AFNOR 1985a)
- Deviations:
- no
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- A stock solution of the substance at a concentration of 100 g/L was initially prepared in bi-distilled water.
Dilutions of this initial solution were then performed with reconstitued river water, normalised at pH 8. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Test type:
- other: According to guideline AFNOR T 90 303
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 24 h
- Post exposure observation period:
- No data.
- Hardness:
- No data.
- Test temperature:
- No data.
- pH:
- pH 8.00
- Dissolved oxygen:
- No data.
- Salinity:
- No data.
- Nominal and measured concentrations:
- No data.
- Details on test conditions:
- No data.
- Reference substance (positive control):
- yes
- Remarks:
- sodium nitrilotriacetate
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 850 mg/L
- Nominal / measured:
- nominal
- Basis for effect:
- mortality (fish)
- Details on results:
- The LC50 (to danio rerio (zebra fish)) after 24h was >1800 mg/L.
- Results with reference substance (positive control):
- Toxicity of sodium nitrilotriacetate: CL(I) 40.24H = ca. 900 mg/l
Sodium nitriloacetate was approximately twice as toxic than the test material. - Reported statistics and error estimates:
- No data.
- Sublethal observations / clinical signs:
Table 1 - Results
Test Material Concentration
(mg/l)
pH Solution
Percentage of Mortality
(at 24h)
2000
10.0
100
1800
9.8
40
1600
9.7
0
1400
9.5
0
1200
9.3
0
0
7.4
0
- Validity criteria fulfilled:
- yes
- Conclusions:
- The acute toxicity of the test item to the freshwater zebrafish (Danio rerio) has been investigated and gave a 24-Hour LC50 of greater than 1800 mg/L.
Reference
Description of key information
Four studies are available for the short-term toxicity to fish. The tests were performed using analogous substance pentasodium triphosphate which is considered suitable in the assessment of pentapotassium triphosphate for the reasons stipulated in the discussion below.
- The study conducted by Dion M (1985) is considered the key study as, although it has not been conducted to OECD guidelines, it is well documented and in accordance with national standard methods (AFNOR T 90 303). Results from this study must be treated with some caution as testing was only performed for 24h. The acute fish toxicity of the test material was 1850 mg/L.
- The second study (Kastner W, 1983) only provided a value of CL0 (highest tested concentration without effects).
- The remaining studies provide additional support for the conclusion that the test material is not considered to be classified according to Regulation (EC) No 1272/2008.
In section 6.1.2 of this dossier a study performed following similar methods to OECD guideline 212 (short term toxicity test on embryo and sac-fry) has also been submitted (LOEC = 5 mg/L).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1 850 mg/L
Additional information
Read across from pentasodium triphosphate to pentapotassium triphosphate is justified on the following basis:
Both substances are inorganic compounds containing a triphosphate anion and a group 1 alkali metal cation. Both sodium and potassium cations are ubiquitous in natural waters and are considered to possess similar toxicological and ecotoxicological profiles due in part to their similar behaviour and their existence as essential micronutrients. The triphosphate anion in both substances will breakdown in the environment via the processes of hydrolysis, biotic degradation and assimilation by organisms in the environment, resulting in the breakdown products of pyrophosphate and orthophosphate anions. Ultimately, pyrophosphate anions will also breakdown to orthophosphate.
It is therefore considered to be scientifically unjustified to conduct further testing on pentapotassium triphosphate as the read across can be adequately justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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