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EC number: 209-599-5 | CAS number: 587-26-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10 Feb 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Qualifier:
- according to guideline
- Guideline:
- other: ISO 13317-2, Determination of particle size distribution by gravitational liquid sedimentation methods - Part 2: Fixed pipette method.
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Landesamt für Umwelt, Wasserwirtschaft und Gewerbeaufsicht, Kaiser-Friedrich-Straße 7, 55116 Mainz, Germany
- Type of method:
- sedimentation (gravitational settling)
- Type of distribution:
- other: gravitational liquid sedimentation
- No.:
- #1
- Size:
- < 3.26 µm
- Distribution:
- 3.22 %
- No.:
- #2
- Size:
- < 6.24 µm
- Distribution:
- 9.66 %
- No.:
- #3
- Size:
- < 9.02 µm
- Distribution:
- 12.9 %
- No.:
- #4
- Size:
- < 13.16 µm
- Distribution:
- 16.39 %
- No.:
- #5
- Size:
- < 18.38 µm
- Distribution:
- 23.9 %
- No.:
- #6
- Size:
- < 26.5 µm
- Distribution:
- 39.72 %
- No.:
- #7
- Size:
- < 38.17 µm
- Distribution:
- 59.81 %
- No.:
- #8
- Size:
- < 49.14 µm
- Distribution:
- 77.23 %
- No.:
- #9
- Size:
- < 64.53 µm
- Distribution:
- 81.81 %
- No.:
- #10
- Size:
- < 113.62 µm
- Distribution:
- 94.12 %
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission, Directorate general XII- JRC, Science Research and Development-Joint Research centre. "Particle size distribution, fibre length and diameter distribution". Guidance document, ECB/TM/February 1996.
- Qualifier:
- according to guideline
- Guideline:
- other: European Commission, Directorate general JRC, Joint Research Centre. "Particle size distribution, fibre length and diameter distribution". Draft guidance document, EUR 20268 EN (2002), Part 5.2 "Laser scattering / diffract".
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Swiss federal office of public health, Bern, Switzerland
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- counted distribution
- Percentile:
- D10
- Mean:
- < 6.6 µm
- St. dev.:
- 0.153
- Percentile:
- D50
- Mean:
- < 29.6 µm
- St. dev.:
- 0.636
- Percentile:
- D90
- Mean:
- < 52 µm
- St. dev.:
- 2.25
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (in analytical certification of test substance)
- GLP compliance:
- not specified
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- volumetric distribution
- Percentile:
- D10
- Mean:
- 30.7 µm
- Percentile:
- D50
- Mean:
- 78.8 µm
- Percentile:
- D90
- Mean:
- 164.5 µm
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 8 Sep 2004
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (comparable to guideline/standards)
- Principles of method if other than guideline:
- The particle size distribution was analyzed using an ANDERSEN cascade impactor (the individual impactor stages (glass plates) were subjected to gravimetric analysis). The determination was part of an acute inhalation study, in which the test substance was aerosolized using a Wright-Dust-Feeder.
- GLP compliance:
- not specified
- Type of distribution:
- volumetric distribution
- Percentile:
- D50
- Mean:
- 6.93 µm
- Remarks on result:
- other: Migrated from fields under 'Mass median diameter' as D50 percentile. No source field for Standard deviation.
- No.:
- #1
- Size:
- 0.01 - 0.4 µm
- Distribution:
- 0 %
- No.:
- #2
- Size:
- 0.4 - 0.7 µm
- Distribution:
- 0 %
- No.:
- #3
- Size:
- 0.7 - 1.1 µm
- Distribution:
- 0.83 %
- No.:
- #4
- Size:
- 1.1 - 2.1 µm
- Distribution:
- 3.04 %
- No.:
- #5
- Size:
- 2.1 - 3.3 µm
- Distribution:
- 8.56 %
- No.:
- #6
- Size:
- 3.3 - 4.7 µm
- Distribution:
- 19.61 %
- No.:
- #7
- Size:
- 4.7 - 5.8 µm
- Distribution:
- 9.94 %
- No.:
- #8
- Size:
- 5.8 - 9 µm
- Distribution:
- 23.2 %
- No.:
- #9
- Size:
- 9 - 30 µm
- Distribution:
- 34.81 %
Referenceopen allclose all
In both experiments, sedimentation took place already before the first sampling time: in the two experiments, 7.3% resp. 8.8% of the particles were not retrieved when determining the 100% value. These particles must be considered as larger than the upper Stokes diameter. The distribution in the table about the "particle size distribution at different passages" applies only to the measurable part.
Lanthanum carbonate is a fine, white, compact powder. Under the microscope (with a magnification of 400) colourless, cubic crystalline structures were observed.
A solubility test showed, that the test item is both: sparingly soluble and well dispersible in water.
The particle size distribution was found to range from approximately 0.3 µm to 100 µm.
Particle size distribution:
|
1stRun Particle Size |
2ndRun Particle Size |
3rdRun Particle Size |
4thRun Particle Size |
Mean Particle Size |
Stand. |
[%] |
[µm] |
[µm] |
[µm] |
[µm] |
[µm] |
[±] |
5 |
3.48 |
3.69 |
3.45 |
3.76 |
3.6 |
0.153 |
10 |
6.28 |
6.76 |
6.25 |
7.08 |
6.6 |
0.400 |
50 |
29.36 |
28.76 |
29.99 |
30.15 |
29.6 * |
0.636 |
90 |
51.80 |
49.15 |
54.62 |
52.40 |
52.0 |
2.250 |
*) The MMD of the test item indicates that 50 % (by mass) of the particles are smaller than 29.6 µm.
The results obtained during the measurements showed no relevant difference. Therefore the study is considered to be valid and no further testing is necessary.
The standard deviation was not specified.
Sample 1:
Mass median aerodynamic diameter (MMAD): 6.93 µm
Geometric standard deviation (GSD): 2.07
Number median aerodynamic diameter (NMAD): 1.43 µm
Surface median aerodynamic diameter: 4.09 µm
Particle size distribution at different passages: see table above
Respirability:
Respirability |
Mass related |
Number related |
percent < 1.0 µm |
0.5 % (measured) |
31.3 % (extrapolated) |
percent < 3 µm |
12.7 % (measured) |
84.7 % (extrapolated) |
percent < 5.0 µm |
32.9 % (measured) |
95.9 % (extrapolated) |
Sample 2:
Mass median aerodynamic diameter (MMAD): 7.44 µm
Geometric standard deviation (GSD): 2.15
Number median aerodynamic diameter (NMAD): 1.28 µm
Surface median aerodynamic diameter: 4.14 µm
Particle size distribution at different passages:
No. |
Size (µm) |
Distribution (%) |
#1 |
0.1-0.4 |
0 |
#2 |
0.4-0.7 |
0 |
#3 |
0.7-1.1 |
0 |
#4 |
1.1-2.1 |
0.86 |
#5 |
2.1-3.3 |
4.90 |
#6 |
3.3-4.7 |
11.53 |
#7 |
4.7-5.8 |
26.51 |
#8 |
5.8-9.0 |
34.29 |
#9 |
9.0-30.0 |
65.99 |
Respirability :
Respirability |
Mass related |
Number related |
< 1.0 µm |
0.5 % (measured) |
37.3 % (extrapolated) |
< 3 µm |
12.1 % (measured) |
86.7 % (extrapolated) |
< 5.0 µm |
30.3 % (measured) |
96.3 % (extrapolated) |
Description of key information
12.9%: < 9.02 µm, 16.39%: < 13.16 µm, 81.81%: < 64.53 µm (Paulus 2010)
D10 < 6.6 µm, D50 < 29.6 µm, D90 < 52 µm (Weissenfeld 2006)
Additional information
Two studies are available which examined the particle size distribution of Lanthanum carbonate.
In the first study, the particle size distribution was determined with gravitational liquid sedimentation according to ISO 13317-2 (Paulus 2010). Sedimentation took place already before the first sampling time: in the two experiments, 7.3% resp. 8.8% of the particles were not retrieved when determining the 100% value. These particles must be considered as larger than the upper Stokes diameter. The measurable part of the particle size distribution shows no single peaks, but a continous distribution with a main part between 13 and 60 µm, leaving fractions of approx. 20% (calculated from theoretical weight) above 114 µm and less than 15% blow 10 µm. Values for D10, D50 and D90 were not given.
The second study investigated the particle size distribution according to European Commission, Directorate general XII- JRC, Science Research and Development-Joint Research centre. "Particle size distribution, fibre length and diameter distribution". Guidance document, ECB/TM/February 1996 (Weissenfeld 2006). The particle size distribution was assessed using laser diffraction, yielding a D10 value of < 6.6 µm, D50 < 29.6 µm and D90 < 52 µm.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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