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EC number: 203-941-7 | CAS number: 112-16-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets scientific standards with acceptable restrictions (limited documentation)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- occlusive
- Principles of method if other than guideline:
- Skin irritation was tested using an internal standard method (BASF test). Two White Vienna rabbits were used. One side of the back was treated for 20 h and the other side was treated for 1, 5 or 15 min under occlusive conditions. An application site of 2.5 X 2.5 cm was covered with the liquid or powdered and moistened with test substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- Lauroyl chloride
- EC Number:
- 203-941-7
- EC Name:
- Lauroyl chloride
- Cas Number:
- 112-16-3
- Molecular formula:
- C12H23ClO
- IUPAC Name:
- dodecanoyl chloride
- Reference substance name:
- XVIII/195
- IUPAC Name:
- XVIII/195
- Details on test material:
- - Name of test material (as cited in study report): Laurylsaeurechlorid
- Physical state: liquid
- Purity: unknown
- Expiration date of the lot/batch: not reported
- Stability under test conditions: not reported
- Storage condition of test material: not reported
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder
- Weight at study initiation: 2.80 and 2.95 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): approx. 1 ml - Duration of treatment / exposure:
- Experiment 1: 20 h
Experiment 2: 1, 5, or 15 minutes - Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: An application site of 2.5 X 2.5 cm was covered with the liquid (37°C; presumably 1 ml)
REMOVAL OF TEST SUBSTANCE
- Washing (if done):
Experiment 1: No washing was done after the 20 h treatment.
Experiment 2: washing was done in the 1 min, 5 min and 15 min test directly after exposure. Lutrol conc. and 50% (mild detergent) was used.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 20 h exposure
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 2.33
- Max. score:
- 3
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: Necrosis observed in both animals; see table for further details
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 20 h exposure
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 1.67
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 d
- Remarks on result:
- other: see table for further details
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- 15 min exposure
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 d
- Remarks on result:
- other: Necrosis observed in obth animals; see table for further details
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- 15 min exposure
- Time point:
- other: 24 - 48 - 72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible
- Remarks:
- 8 d
- Remarks on result:
- other: see table for further details
Any other information on results incl. tables
Since irritation data from a 4 h skin exposition are recommended, results of the available 20 h and the 15 min exposition served as approximation.
Descriptive scores of the raw data have been converted to Draize numerical scores. If necroses were reported, erythema scores were given for the surrounding area.
Exposition: |
20 h |
|||
Animal |
Reading |
Erythema |
Edema |
Comment |
1 |
24 h |
2 |
2 |
anemic areas, pergamenteous, wrinkles |
2 |
24 h |
2 |
2 |
overlapping, pergamenteous, wrinkles |
1 |
48 h |
2 |
2 |
anemic areas, pergamenteous, wrinkles |
2 |
48 h |
2 |
2 |
overlapping, pergamenteous, wrinkles, edge anemic |
1 |
72 h |
3 |
0 |
light brown, smooth and anemic necrosis |
2 |
72 h |
3 |
2 |
light brown, partly anemic necrosis |
1 |
6 d |
? |
0 |
light brown, not smooth necrosis |
2 |
6 d |
0 |
0 |
light brown, not smooth necrosis |
1 |
8 d |
2 |
0 |
necrosis, partly detaching |
2 |
8 d |
0 |
0 |
leather-like necrosis, partly detaching, scaling in the surrounding area |
mean |
24 - 72 h |
2.33 |
1.67 |
|
Exposition: |
15 min |
|||
Animal |
Reading |
Erythema |
Edema |
Comment |
1 |
24 h |
2 |
0 |
overlapping |
2 |
24 h |
2 |
2 |
overlapping, pergamenteous |
1 |
48 h |
2 |
0 |
overlapping, anemic areas |
2 |
48 h |
2 |
2 |
overlapping, pergamenteous with some pin-head sized anemic areas |
1 |
72 h |
2 |
2 |
overlapping, anemic areas |
2 |
72 h |
2 |
2 |
overlapping, pergamenteous with anemic areas |
1 |
6 d |
0 |
0 |
light, superficial necrosis |
2 |
6 d |
0 |
0 |
light brown, pergamenteous necrosis |
1 |
8 d |
0 |
0 |
light, superficial necrosis |
2 |
8 d |
0 |
0 |
light brown, pergamenteous necrosis, detaching |
mean |
24 - 72 h |
2.00 |
1.00 |
|
Applicant's summary and conclusion
- Executive summary:
This study meets scientific standards with acceptable restrictions (limited documentation). Skin irritation was tested using an internal standard method (BASF test). White Vienna rabbits were used. 2 animals were treated for 1, 5 and 15 minutes and for 20 hours using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with the test substance.
The test substance induced slight superfacial necrosis after 15 min exposure and full thickness necrosis after 20 h exposure under these harsh occlusive conditions. In conclusion, Lauroyl chloride is classified as corrosive to the skin (R34 according to EU classification criteria and skin corrosion Cat 1C according to GHS classification criteria).
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