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Diss Factsheets
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EC number: 228-601-5 | CAS number: 6303-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Justification of the read across:
In the current assessment, data from sodium phosphinate were used to evaluate the phosphinic acid properties. Phosphinic acid is commercially prepared as the result of pH adjustement of the sodium phosphinate salt. The main assumption is that sodium is not significant in respect of all the properties under consideration which are expected to be related to the phosphinate anion. In dilute aqueous conditions of environmental pH (5-9) the salt will behave no differently to the parent acid, at identical concentration of the particular speciated form present and will be fully dissociated.
In human health hazard assessment, irritant and corrosive properties are studied on the phosphinic acid itself due to the low pH of the acid form, as a read-across approach is not relevant. However as mutagenicity tests and long term toxicity tests are performed in dilute aqueous conditions, no pH effect is expected and only intrinsic properties of the active compound is studied. Therefore the read across approach is applied in the present dossier. - Reason / purpose for cross-reference:
- read-across source
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Sex:
- male
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: limit test: no mortality
- Sex:
- female
- Dose descriptor:
- approximate LD50
- Effect level:
- <= 5 000 mg/kg bw
- Remarks on result:
- other: limit test: mortality 6/10
- Sex:
- male
- Dose descriptor:
- approximate LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: limit test: mortality 3/10
- Mortality:
- - At 2000 mg/kg , no deaths occurred in male rats.
- At 5000 mg/kg, 3 out of 10 males and 6 out 10 females died on day 2.
- In the negative control groups, no deaths occurred. - Clinical signs:
- other: - In males exposed to 2000 mg/kg, mild depression and piloerection were observed from day 1 (1 hour after dosing) to day 2. - In males and females exposed to 5000 mg/kg, mild depression and piloerection were observed from day 1 (immediately after dosing)
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- discriminating dose
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- The potential toxicity of sodium phosphinate following a single oral administration in rats was investigated according to OECD guideline 401 and methods similar to OPPTS 870.1100. As phosphinic acid is generated from sodium phosphinate, toxicity for the two substance are considered as similar.
Phosphinic acid is of low toxicity by oral administration.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
According to the criteria laid down in EU regulation (EC) n° 1272/2008/EC (CLP) and EU directive 67/548/EEC, phosphinic acid is classified as corrosive for the skin and eyes. Considering these properties, no data was generated for acute toxicity of the substance.
Moreover, read across data on sodium phosphinate tested in oral route showed no adverse effect at 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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