Registration Dossier
Registration Dossier
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EC number: 231-211-8 | CAS number: 7447-40-7
Endpoint summary
Administrative data
Description of key information
Groups of male F344/Slc rats received 110, 450, 1820 mg/kg bw/day of KCl in feed over a period of 2 years. The NOAEL was set 1820 mg/kg bw/day since nephritis was reported in all treatment groups as well as in the control group. With respect to the observed gastritis which is regarded to be a local effect a LOAEL(local) of 110 mg/kg bw/d was determined (Imai 1961, UNEP 2003).
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 820 mg/kg bw/day
- Study duration:
- chronic
- Species:
- rat
Additional information
ORAL APPLICATION
Groups of male F344/Slc rats received 110, 450, 1820 mg/kg bw/day of KCl in feed over a period of 2 years and were observed for clinical signs and mortality and were examined for gross and histopathological changes at the end of the treatment period (Imai 1961) The NOAEL was set 1820 mg/kg bw/day since nephritis was reported in all treatment groups as well as in the control group.
With respect to the observed gastritis which is regarded to be a local effect a LOAEL(local) of 110 mg/kg bw/d was determined (Imai 1961, UNEP 2003).
DERMAL APPLICATION
There is no data available on dermal repeated dose toxicity for potassium chloride.
APPLICATION VIA INHALATION ROUTE
There are no data availabel on repeated dose toxicity using the inhalation route for potassium chloride.
Justification for classification or non-classification
Based on the available data no classification/labelling is proposed
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