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EC number: 236-671-3 | CAS number: 13463-41-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Pyrithione zinc
- EC Number:
- 236-671-3
- EC Name:
- Pyrithione zinc
- Cas Number:
- 13463-41-7
- Molecular formula:
- C10H8N2O2S2Zn
- IUPAC Name:
- Bis [1-hydroxy-2(1H)-pyridinethionato-O,S](T-4)-zinc
- Details on test material:
- Purity: 97.9%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Source: Charles River Germany
Sex: Female
Weight at study initiation: 1.7kg
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 84mg
- Duration of treatment / exposure:
- 24h
- Observation period (in vivo):
- 24h
- Number of animals or in vitro replicates:
- 1
- Details on study design:
- Opthalmoscopic examinations: 60min and 24h
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24h
- Reversibility:
- not reversible
- Remarks on result:
- other: no ophthalmological examination possible
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 24h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Severe and irreversible corneal lesions (corneal perforation suspected, leakage of aqueous humor), severe redness and swelling (score 3 and 4) were noted 24 h p.a. No observation of the iris was possible because of the severity of chemosis and of corneal alterations.
Due to the severity of lesions the animal was euthanised 24 h p.a. and no additional animals were administered.
Any other information on results incl. tables
Table 1. Results of eye irritation study
|
||||
|
Cornea |
Iris |
Conjunctiva |
|
redness |
chemosis |
|||
score (of one animal investigated) |
0 to 4 |
0 to 2 |
0 to 3 |
0 to4 |
60 min |
no ophthalmological examination possible |
no ophthalmological examination possible |
1 |
4 |
24 h |
4 |
no ophthalmological examination possible |
3 |
4 |
48 h |
* |
* |
* |
* |
72 h |
n.a. |
n.a. |
n.a. |
n.a. |
Average 24h, 48h, 72h |
n.a. |
n.a. |
n.a. |
n.a. |
Area effected |
gross destruction |
|
|
|
Maximum average score (including area affected, max 110) |
n.a. |
n.a. |
n.a. |
n.a. |
Reversibility* |
no |
no |
no |
no |
average time for reversion |
n.a. |
n.a. |
n.a. |
n.a. |
Give method of calculation maximum average score. * c : completely reversible |
n.a. |
n.a. |
n.a. |
n.a. |
* The one animal was killed at 24 h for humane reasons.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Zinc Pyrion technical powder Type A causes irreversible ocular lesions and poses a "risk of serious damage to eyes". This information may not be used for any purpose other than in support of the Chemical safety Report submitted by Arch Chemicals Inc. under Regulation EC 1907/2006.
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