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EC number: 201-132-3 | CAS number: 78-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
The aquatic toxicity of AZDN has been assessed for three trophic level under acute and long-term exposures. The Japanese dataset was not considered as robust enough for characterizing AZDN ecotoxicity as the tests were carried out at concentrations which are far below the water solubility of AZDN (10 mg/L tested versus >300 mg/L water solubility). A new algae test was carried out for strengthening the picture.
The 96-h LC50 of fish Danio rerio is greater than 100 mg/l and less than 500 mg/l. When Oryzias latipes were exposed to varying concentrations of AZDN over 14 days, the NOEC and LC50 of the test substance was found to be not less than 10mg/L.
In the Daphnia magna test, the highest concentration of AZDN tested (367 mg/l) did not show a significant immobilisation following the 48 hours exposure.
The concentrations of test item causing a 50 % reduction in biomass (EbC50) and in growth rate (ErC50) for algae within 72 -h were estimated to be 3.9 and 4.5 mg/L respectively. It was possible to determine the No Observable Effect Concentrations (NOEC) which is 1.48 mg/L for both biomass and growth rate.
Long-term test for Daphnia was carried out at concentrations which did not induce mortality.
A Daphnia reproduction study was conducted according to OECD 202 but included reproduction for 21 days rather than 14 days, found that the 21 day 50% lethal concentration (LC50) in parental Daphnia magna was found to be >10 mg/L, whilst the 21 day 50% reproduction inhibition concentration (ErC50) was 7.5 mg/L (95% confidence interval 4.6 -10 mg/L). The maximum no-observed-effect concentration (NOECr) was 2.2 mg/L and the lowest-observed-effect concentration (LOECr) was 4.6 mg/L.
A fish sub-acute toxicity study was conducted at Sumika Technos Corp, Japan to investigate the thresholdsfor lethal and other effects of AZDN. The test type was a flow through study conducted to GLP and according to OECD Guideline 204 and involved exposing the speciesOryzias latipesto the test substance dissolved in the water at nominal concentrations of 1.0, 1.8, 3.2, 5.6 and 10 mg/L over a 14 day period. The fish were observed over the test period for differences in weight, length, behaviour and mortality. At the end of the 14 day exposure period, the no overall effect concentration NOEC was found to be =
10mg/L and the LC50 (the 50% lethal concentration) was estimated to be >10 mg/L. No data are available concerning potential sediment organisms toxicity. Nevertheless based on the expected behaviour of AZDN when released in the environment and its intrinsic properties, one can safely conclude that organisms inhabiting sediments will not be exposed to AZDN. Therefore additional tests on those species are not considered.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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