Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 618-561-0 | CAS number: 9046-10-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982-08-30 to 1982-09-02
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Remarks:
- Limited details were provided on the test substance (e.g., purity was lacking) and environmental conditions of animals. Details on measurement of the area of test application site was missing, but it can be assumed that it was smaller than the recommended 6cm^2 based on the patch that covered it was only 1 in^2. Observations were only made at 4 and 44 hours after test substance administration.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Limited details were provided on the test substance (e.g., purity was lacking) and environmental conditions of animals. Details on area of test application site was missing. Observations were only made at 4 and 44 hours.
- GLP compliance:
- no
Test material
- Test material form:
- liquid
- Details on test material:
- - Physical state: liquid
- Storage condition of test material: Room temperature
Constituent 1
- Specific details on test material used for the study:
- - Name as cited in study report: poly[oxy(methyl-1,2-ethanediyl)], alpha-(2-aminomethylethyl)-omega-(2-aminomethylethoxy)
- Substance type: Active
- Color: clear
- Storage: no change in physical state of test substance during administration
-Lot: 5601-9-1, order#J-154
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Perfection Breeders, Douglassville, Pennsylvania
- Weight at study initiation: 2-3 kg
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 1982-08-30To: 1982-09-01
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml was applied once directly on the intact skin site (one non-abraded skin site per animal). - Duration of treatment / exposure:
- 4 hours
- Observation period:
- Animals were observed at 4 and 44 hours after treatment.
- Number of animals:
- 3 males and 3 females
- Details on study design:
- TEST SITE
- Area of exposure: All application sites were clipped free of fur and non-abraded. No further information was provided on the area of exposure.
- Type of wrap if used: Following the application of the test substance, one-inch square gauze patches were applied to the test site. The trunk of the animal was then wrapped with a rubber dam and an Ace bandage to retard evaporation.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): At the end of the four hour exposure period, the wrappings were removed and the skin was wiped to remove any remaining test substance.
- Time after start of exposure: 4 hours
SCORING SYSTEM: Corrosion was considered to have resulted if the test substance in contact with the rabbit skin had caused destruction or irreversible alteration of the tissue on at least two out of each six rabbits tested. Tissue destruction was considered to have occurred if at any of the readings there was ulceration or necrosis.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4h
- Remarks on result:
- other: visible
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 44h
- Remarks on result:
- other: visible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4h
- Remarks on result:
- other: visible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 44h
- Remarks on result:
- other: visible
- Irritation parameter:
- other: necrosis
- Basis:
- mean
- Time point:
- other: 4h
- Remarks on result:
- other: visible in 2 out of 6 rabbits
- Irritation parameter:
- other: necrosis
- Basis:
- mean
- Time point:
- other: 44h
- Remarks on result:
- other: visible in 5 out of 6 rabbits
- Irritant / corrosive response data:
- Erythema and edema were visible at 4 and 44 hours after treatment. Signs of necrosis were visible in two of six rabbits at the 4 hour reading and in five of six rabbits at the 44 hour observation period. Based upon the results, the test substance was considered to be corrosive.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Conclusions:
- The test substance was evaluated for primary dermal corrosivity in rabbits. Based on the results of the study, the test substance was determined to be corrosive and considered to be classified as category 1C according to CLP Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)
Iako ECHA većinu materijala na ovim stranicama osigurava na vašem jeziku, dio ove stranice samo je na engleskom. Dodatne informacije o politici višejezičnosti ECHA-e.
Dobro došli na stranice ECHA-e Ove stranice ne podržavaju potpuno Internet Explorer 7 (i njegove ranije inačice). Preuzmite noviju inačicu Internet Explorera.
Na ovom portalu koristimo kolačiće kako bismo vam osigurali najbolje iskustvo njegova pregledavanja.
Saznajte više o tome kako upotrebljavamo kolačiće.