Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 212-222-7 | CAS number: 770-35-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study according to OECD guideline 406.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4100 (Skin Sensitisation)
- Qualifier:
- according to guideline
- Guideline:
- other: MAFF Dermal Sensitization Study, 1985.
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes
- Type of study:
- Buehler test
Test material
- Reference substance name:
- 1-phenoxypropan-2-ol
- EC Number:
- 212-222-7
- EC Name:
- 1-phenoxypropan-2-ol
- Cas Number:
- 770-35-4
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-phenoxypropan-2-ol
- Reference substance name:
- 1-phenylpropan-2-ol
- EC Number:
- 211-821-0
- EC Name:
- 1-phenylpropan-2-ol
- Cas Number:
- 698-87-3
- IUPAC Name:
- 1-phenylpropan-2-ol
- Details on test material:
- Identity: Dowanol-PPh (1-phenoxy-2-hydroxypropane or
propylene glycol phenyl ether)
CAS # 770-35-4 (also 41593-38-8)
Batch No.: LE08011T01
Purity: 93.7%
Supplied as: Not reported
Appearance: Liquid
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories
- Age at study initiation: approximately 58 days
- Weight at study initiation: not specified
- Housing: Animals were housed five per cage.
- Diet (e.g. ad libitum): The animals were supplied with Purina Certified Guinea Pig Chow #5026 obtained from the Purina Mills Inc., St. Louis, Missouri ad libitum.
- Water (e.g. ad libitum): The animals were supplied with tap water ad libitum.
- Acclimation period: atleast one week prior to study start
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3°C
- Humidity (%): 40-70%
- Air changes (per hr): 15 times/hour
- Photoperiod (hrs dark / hrs light): 12 hour light/dark photocycle
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 0.4 ml of neat Dowanol PPh
Challengeopen allclose all
- Route:
- epicutaneous, occlusive
- Vehicle:
- unchanged (no vehicle)
- Concentration / amount:
- 0.4 ml of neat Dowanol PPh
- No. of animals per dose:
- 20 treatment group + 10 control group
- Details on study design:
- RANGE FINDING TESTS: A preliminary skin irritation screen was conducted in order to determine a slightly irritating dose, if obtainable, as well as to establish the highest non-irritating concentration of the test material. Guinea pigs were clipped free of hair on the left and right side, and on their back, the day prior to dosing. Single applications of 0.4 ml of neat DOWANOL PPh, or applications of 0.1%, 0.5%, 1%, 5%, 10%, 25%, 50% or 75% dilutions of
DOWANOL PPh Glycol Ether in 0.5% Methocel* were topically applied to the skin of guinea pigs for six hours in Hill Top Chambers (25 mm Hill Top Chamber, Hill Top Research Inc., Cincinnati, Ohio). Two animals per dilution were used for the screen phase. An aliquot of neat DOWANOL PPh or an aliquot of a DOWANOL PPh dilution was placed in the chamber and applied to the animal. The following morning the application sites were depilated. Approximately five to six hours after depilation, the dermal test sites were graded for erythema and edema. Skin irritation readings were recorded approximately 24 and 48 hours after test material removal. Multiple animals were used to determine that 0.4 ml of neat DOWANOL PPh did not cause any irritation in screen animals and would, therefore, be used for the induction and challenge applications.
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 3
- Exposure period: 6 hours
- Test groups: one (A single 0.4 ml aliquot of neat Dowanol PPh was applied in Hill Top Chambers to the left side of 10 male guinea pigs
- Site: The left side of ten guinea pigs per treatment group were clipped free of hair the day prior to dosing.
- Frequency of applications: single at weekly intervals for a total of 3 consecutive weeks
- Duration: single at weekly intervals for a total of 3 consecutive weeks
- Concentrations: 0.4 ml of neat Dowanol PPh
The left side of ten guinea pigs per treatment group were clipped free of hair the day prior to dosing. A single 0.4 ml aliquot of neat DOWANOL PPh was applied in Hill Top Chambers to the left side of ten male guinea pigs. The chambers were secured with Vetrap® which was held in place with Elastikon™ and removed after approximately a sixhour exposure period. The application site was washed with tap water moistened disposable towels. Observations for erythema/edema were recorded the following day. The animals were clipped and the respective groups were treated with the test material in the same manner at weekly intervals for a total of three consecutive weeks.
B. CHALLENGE EXPOSURE
- No. of exposures: single
- Day(s) of challenge: Approximately two weeks after the last induction application
- Exposure period: 6 hours
- Test groups: same as in induction phase. Also, five naive animals were dosed with a single 0.4 ml aliquot of neat DOWANOL PPh
- Site: Approximately two weeks after the last induction application, the right side of each animal was clipped free of hair. A single 0.4 ml aliquot of neat DOWANOL PPh, a non-irritating dose, was applied to the right side of the guinea pigs in the same manner as in the induction phase.
- Concentrations: single 0.4 ml aliquot of neat DOWANOL PPh
- Evaluation (hr after challenge): approximately 24 and 48 hours after the challenge application
Approximately two weeks after the last induction application, the right side of each animal was clipped free of hair. A single 0.4 ml aliquot of neat DOWANOL PPh, a non-irritating dose, was applied to the right side of the guinea pigs in the same manner as in the induction phase. Also, five naive animals were dosed with a single 0.4 ml aliquot of neat DOWANOL PPh. The test material was removed after approximately a six-hour exposure period and the application site was washed with tap water moistened disposable towels. The following day the challenge application sites were depilated approximately five to six hours prior to scoring. The application sites were observed and graded for sensitization response or irritation approximately 24 and 48 hours after the challenge application. - Challenge controls:
- not applicable
- Positive control substance(s):
- yes
- Remarks:
- Results of the AHCA and DNCB positive control study were appended to the study report (Refer to attachments)
Study design: in vivo (LLNA)
- Vehicle:
- other: not applicable
- Concentration:
- not applicable
- No. of animals per dose:
- not applicable
- Details on study design:
- not applicable
- Positive control substance(s):
- other: not applicable
- Statistics:
- Means and standard deviations were calculated for body weights. The data were evaluated for statistical outliers by a sequential test, however, outliers were not routinely excluded from statistical analysis.
Results and discussion
- Positive control results:
- Refer to attachment
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.4 ml of 100% DOWANOL PPh
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no clinical signs of toxicity noted
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 0.4 ml of 100% DOWANOL PPh. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: no clinical signs of toxicity noted.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 0.4 ml of 100% DOWANOL PPh
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no clinical signs of toxicity noted
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 0.4 ml of 100% DOWANOL PPh. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: no clinical signs of toxicity noted.
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Remarks on result:
- other: not applicable
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: not applicable
Any other information on results incl. tables
none
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of the study, Dowanol PPh did not cause contact hypersensitivity when tested in guinea pigs and hence classified as not sensitizing
- Executive summary:
DOWANOL PPh Glycol Ether, 94.0% purity, was evaluated for dermal sensitization potential using the Buehler method. Twenty male Hartley albino guinea pigs received three single dermal applications of 0.4 ml of neat DOWANOL PPh Glycol Ether at weekly intervals during the three-week induction period and during the challenge period. Ten naive animals also received 0.4 ml of neat DOWANOL PPh during the challenge phase. The condition of the test sites was assessed approximately 24 and 48 hours after the challenge application. Challenge application with 0.4 ml of neat DOWANOL PPh did not cause any irritation in any of the induced animals 24 or 48 hours after the challenge dose. No irritation was observed on any of the naive animals. All animals were in apparent good health and gained body weight over the duration of the study. Therefore, under the conditions of this study, DOWANOL PPh did not cause delayed contact hypersensitivity in guinea pigs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.