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Diss Factsheets
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EC number: 629-850-6 | CAS number: 1245638-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From September 25, 1980 to October 28, 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the equivalent of standard guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Method: 40 CFR Part 163.81-2 (Environmental Protection Agency, Pesticide Programs. Proposed Guidelines for Registering Pesticides in the U.S.; Hazard Evaluation: Humans and Domestic Animals. Acute Dermal Toxicity Study)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2-Propenoic acid, reaction products with pentaerythritol
- EC Number:
- 629-850-6
- Cas Number:
- 1245638-61-2
- Molecular formula:
- Not available for this UVCB.
- IUPAC Name:
- 2-Propenoic acid, reaction products with pentaerythritol
- Details on test material:
- Name of test material (as cited in study report): SN-2196, C-171, JAB 318-80
Physical state: Viscous, clear liquid
Density: 1.1788 g/mL
Storage condition of test material: Stored at room temperature
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Penn Dutch Laboratory Animals Denver, Pennsylvania
- Age at study initiation: Young adults
- Weight at study initiation: Males: 2.2-2.8 kg and females: 2.5-2.9 kg
- Housing: Individually in suspended stainless steel cages
- Diet (e.g. ad libitum): Purina Rabbit Chow, ad libitum
- Water (e.g. ad libitum): Municipal water, ad libitum
- Acclimation period: 19 d
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 60-66 °F
- Photoperiod (h dark / h light): 12 h dark / 12 h light
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- TEST SITE
- % coverage: 10 % of the body surface area
- Type of wrap if used: Test material applied directly, covered by gauze and then wrapped with an impervious plastic sleeve
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Test site wiped free of excess test material
- Time after start of exposure: 24 h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 1.7 mL/kg
- Concentration (if solution): 2,000 mg/kg - Duration of exposure:
- 24 h
- Doses:
- 2,000 mg/kg bw
- No. of animals per sex per dose:
- Six males and four females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 d
- Frequency of observations: Animals were observed twice daily for viability check; pharmacological/toxicological signs were observed at 1, 2 and 4 h after dosing and daily thereafter for 14 d; weighed at pre-dose (at the time of clipping), day of dosing , days 7 and 14 or at terminal sacrifice
- Necropsy of survivors performed: Yes; surviving animals were killed by intravenous overdose of sodium pentobarbital
- Other examinations performed: Local irritation reactions were observed 30 min after removal of test material - Statistics:
- No data
Results and discussion
- Preliminary study:
- Not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- discriminating dose
- Effect level:
- 2 000 mg/kg bw
- Mortality:
- All animals survived throughout the study period
- Clinical signs:
- other: - Nasal and/or oral or ocular discharge were observed in several animals during the 14-d post-dose period - Fecal staining of the abdomen was observed in one animal at 24 h
- Gross pathology:
- Necropsy revealed abnormalities like small or pale spleen; red foci in adrenals; raised, yellow and hard seminal vesicles; tan lungs; stomach or small intestines extremely distended with gas.
- Other findings:
- - Decreased food consumption was observed in one animal
Local irritation reactions at application site:
- Well-defined to severe erythema with moderate or severe edema at 24 h
- Two animals exhibited eschar at the dosing site at terminal necropsy
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the study, the acute dermal LD50 of C-171 in male/female rabbits was > 2,000 mg/kg bw. The discriminating dose is 2,000 mg/kg bw.
- Executive summary:
A study was conducted to assess the acute dermal toxicity of C-171 in New Zealand White rabbits using the method equivalent or similar to OECD Guideline 402.
A group of 6 male and 4 female New Zealand White rabbits received a single dermal application of 2,000 mg/kg bw at a dose volume of 1.7 mL/kg to a shaved area of the back representing 10 % of the total body surface area. The application was occluded and exposure was for 24 h. Parameters evaluated included survival, clinical observations, body weight and necropsy findings in all animals after a 14 days observation period.
No mortality occured at 2,000 mg/kg bw. All animals, except one male and one female, showed body weight gain during the study.
Clinical signs noted in several animals were nasal and/or oral or ocular discharge. Decreased food consumption and fecal staining of the abdomen were observed in one animal at 24 h. Well-defined to severe erythema with moderate or severe edema were observed at the application site at 24 h. Two animals exhibited eschar at the dosing site at terminal necropsy. Necropsy revealed abnormalities like small or pale spleen; red foci in adrenals; raised, yellow and hard seminal vesicles; tan lungs; stomach or small intestines extremely distended with gas.
In conclusion, under the conditions of the study, the acute dermal LD50 of C-171 in male/female rabbits was > 2,000 mg/kg bw. The discriminating dose is 2,000 mg/kg bw.
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