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Diss Factsheets
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EC number: 201-116-6 | CAS number: 78-42-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dissociation constant
Administrative data
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 25 June 2012 to 30 January 2013
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- The test was conducted on tris(2-ethylhexyl) phosphate which has low solubility. Titration was used as the method to determine the dissociation constant. This method is inappropriate for low solubility substances. Furthermore the test concentration used was several times above the limit of solubility. Purity of the substance is unknown. Based on the use of an inaporpriate method and the uncertainty pertaining the complete solubilization of the test substance within the test system, as well as possible impurities of the substance, the study is not reliable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Deviations:
- yes
- Remarks:
- titration method was used for a low solubility substance. Spectrophotometric methods should be employed, not titration
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Tris(2-ethylhexyl)phosphate
- IUPAC Name:
- Tris(2-ethylhexyl)phosphate
- Reference substance name:
- Tris(2-ethylhexyl) phosphate
- EC Number:
- 201-116-6
- EC Name:
- Tris(2-ethylhexyl) phosphate
- Cas Number:
- 78-42-2
- Molecular formula:
- C24H51O4P
- IUPAC Name:
- tris(2-ethylhexyl) phosphate
- Test material form:
- other: liquid
- Details on test material:
- Batch number: CH3/01031
Molecular weight: 434.64
Molecular formula: C24H51O4P
Manufacture date: April 2012
Expiry date: April 2013
Constituent 1
Constituent 2
Results and discussion
- Dissociating properties:
- no
Any other information on results incl. tables
According to the results the test substance did not dissociate.
Applicant's summary and conclusion
- Conclusions:
- The test substance does not dissociate.
- Executive summary:
An OECD 112 test was conducted to determine the dissociation constant of tris(2 -ethylhexyl)phosphate.
The titration method was used, using NaOH and HCl as the titrant, and the substance (~4 g) was placed in 1000 mL of ultrapure water to lead to a solution of tris(2 -ethylhexyl)phosphate of 0.01 mol/L.
The test substance did not dissociate during this test.
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