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EC number: 237-898-0 | CAS number: 14059-33-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- non-GLP study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
- Reference Type:
- other: TSCA 8e
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Bismuth vanadium tetraoxide
- EC Number:
- 237-898-0
- EC Name:
- Bismuth vanadium tetraoxide
- Cas Number:
- 14059-33-7
- Molecular formula:
- Bi O4 V
- IUPAC Name:
- vanadium(5+) bismuth(3+) tetraoxidandiide
- Details on test material:
- - Name of test material (as cited in study report): Sicopal-Gelb L-1110
- Physical state: solid
- Composition of test material, percentage of components: 57% BiVO4, 43% BiMoO6
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- head only
- Vehicle:
- other: Aerosil E 200
- Details on inhalation exposure:
- A head-nose inhalation system INA 20 with a volume of ca. 55 L was used during exposure. The substance was dispersed with Aerosil E 200 (5% m/m) to ensure better flowability and the dust-aerosol was generated with a Vibratomat. A variable oscillation amplitude and slit were used to obtain different concentrations. A volumetric flow of 1500 L/h was used during the four hour exposure of the animals. A 10% overpressure in the exposure chamber ensured that the substance-air mixture was not diluted by external air. Determination of the concentration was done gravimetrically. Particle size determination was carried out using an Andersen Stack Sampler Mark III.10 male and 10 female Wistar rats, ca. 8 weeks of age at the beginning of the study, were exposed to 5.15 mg/L of a dust-aerosol of the test substance.
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5.42 +/- 0.093 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.15 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: No mortality occured
- Mortality:
- Mortality did not occur.
- Clinical signs:
- other: Clinical symptoms during exposure included an increased breathing rate. Following exposure, the animals exhibited accelerated or intermittent breathing and scrubby fur. These symptoms had disappeared by day six of exposure.
- Body weight:
- At the beginning of the study, a mean body weight of 263 g and 179 g of the male and female animals, respectively, was recorded. At the end of the study (day 14), the mean body weight of the male and female animals was 334 g and 208 g, respectively. There was no substance related effect on the body weight development of the animals.
- Gross pathology:
- Gross pathology revealed slightly yellow lungs in the sacrificed animals.
Any other information on results incl. tables
The mean analytical concentration was 5.42 mg/L ± 0.093 mg/L (single values: 5.50, 5.33, 5.49, 5.34 mg/L). After deduction of the Aerosol, the mean concentration was 5.15 mg/L.
Particle size determination yielded a mass median aerodynamic diameter 50% of 2.6 µm. The respirable fraction (particles ≤ 5.5 µm) was 88.5%.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- According to the results of this study, the LC50 following four hour inhalation exposure to the test substance was > 5.15 mg/L for male and female Wistar rats.
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