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Diss Factsheets
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EC number: 202-873-5 | CAS number: 100-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Phenylhydrazine was considered a skin and eye irritant.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Non-human data:
Skin irritation
In a single dose toxicity study with rabbits phenylhydrazine hydrochloride was applied to the skin for 24 h moistened with distilled water, under either an occlusive or semi-occlusive dressing, (Derelanko et al., 1987). Skin irritation was seen in all rabbits, with some necrosis at the treated site at 24 h post-application and sloughing of the skin reported in some animals.
In a skin irritation study with rats, signs of irritation appeared within 24 h and persisted for up to 7 days post-exposure. Necrosis developed in a small number of rats.
Eye irritation
In an eye irritation study with rabbits application of a 50 % solution of phenylhydrazine to the eyes of rabbits caused severe suppurative conjunctivitis (Pham, 1979).
Respiratory irritation
No data available.
There was no evidence of corrosive effects to skin or eyes.
Human data:
Skin irritation
Occupational exposure data on skin irritation was available, with several reports following accidental spillage. No irritancy effects were observed in workers exposed to liquid phenylhydrazine following accidental exposure (Schuckmann, 1969). Following dermal contact to phenylhydrazine hydrochloride powder skin irritation effects were reported in two cases. Local irritation, superficial erythema, and partly bullous-papular changes were noted in one case following spillage of powder on arms; multiple burn marks and small blisters at the site of contact were reported in the second case in which phenylhydrazine hydrochloride had spilled into the worker’s gloves and shoes. However, the severity of skin irritation effects may vary.
Eye irritation
No human data was available on the eye irritation potential of phenylhydrazine. There were no reports of corrosive effects from occupational use.
Respiratory irritation
There were no reports of respiratory irritation from occupational use.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: irritating
Justification for classification or non-classification
Skin:
Based on Directive 67/548/EC (DSD) and Regulation 1272/2008/EC (CLP), phenylhydrazine is classified as skin irritant (Xi, R36; cat 2, H315).
Eye:
Based on Directive 67/548/EC (DSD) and Regulation 1272/2008/EC (CLP), phenylhydrazine is classified as eye irritant (Xi, R38; cat 2, H319).
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