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Diss Factsheets
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EC number: 203-577-9 | CAS number: 108-39-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Principles of method if other than guideline:
- static bioassay
- GLP compliance:
- no
- Analytical monitoring:
- no
- Test organisms (species):
- other: see results
- Details on test organisms:
- fish length approximately 5 cm
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 12
- Duration:
- 6 h
- Dose descriptor:
- other: LC50 (Salmo trutta)
- Effect conc.:
- 11 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Salmo trutta
- Duration:
- 24 h
- Dose descriptor:
- other: LC50 (Salmo trutta)
- Effect conc.:
- 8.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Salmo trutta
- Duration:
- 48 h
- Dose descriptor:
- other: LC50 (Salmo trutta)
- Effect conc.:
- 8.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Salmo trutta
- Duration:
- 96 h
- Dose descriptor:
- other: LC50 (Salmo trutta)
- Effect conc.:
- 8.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Salmo trutta
- Duration:
- 6 h
- Dose descriptor:
- other: LC50 (Oncorhynchus mykiss)
- Effect conc.:
- 14.9 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Oncorhynchus mykiss
- Duration:
- 24 h
- Dose descriptor:
- other: LC50 (Oncorhynchus mykiss)
- Effect conc.:
- 10.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Oncorhynchus mykiss
- Duration:
- 48 h
- Dose descriptor:
- other: LC50 (Oncorhynchus mykiss)
- Effect conc.:
- 10.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Oncorhynchus mykiss
- Duration:
- 96 h
- Dose descriptor:
- other: LC50 (Oncorhynchus mykiss)
- Effect conc.:
- 8.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Oncorhynchus mykiss
- Duration:
- 6 h
- Dose descriptor:
- other: LC50 (Salvelinus fontinalis)
- Effect conc.:
- 11.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Salvelinus fontinalis
- Duration:
- 24 h
- Dose descriptor:
- other: LC50 (Salvelinus fontinalis)
- Effect conc.:
- 8.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Salvelinus fontinalis
- Duration:
- 48 h
- Dose descriptor:
- other: LC50 (Salvelinus fontinalis)
- Effect conc.:
- 7.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Salvelinus fontinalis
- Duration:
- 96 h
- Dose descriptor:
- other: LC50 (Salvelinus fontinalis)
- Effect conc.:
- 7.6 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: ; Salvelinus fontinalis
- Details on results:
- In an additional test with Oncorrhynchus mykiss (body length approximately 7.5 cm) under flow-through conditions a concentration of 10 mg/l caused total incapacitation in 15 of 20 fish within 11.5 min, after which a recovery to a higher level of activity was observed
- Sublethal observations / clinical signs:
- For Salvelinus fontinalis at concentrations of 6 to 20 mg/l, the approximate
incidence of surfacing was 20 %Of the 3 isomers of cresols, m-cresol was the least toxic to salmonids
- Executive summary:
The acute toxicity of m-cresol to fish was determined with a static bioassay on several freshwater species. The highest toxicity is a 96h LC50 value of 7.6 mg/L with Salvelinus fontinalis.
Reference
Description of key information
The acute toxicity of m-cresol to fish was determined with a static bioassay on several freshwater species. The highest toxicity is a 96h LC50 value of 7.6 mg/L with Salvelinus fontinalis.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 7.6 mg/L
Additional information
For various fish species short term toxicity tests are available, with LC50 (96h) values ranging from 7.6 to 55.9 mg/l.
The most sensitive fish species in reliable acute toxicity tests belong to the salmonids. An acute static tests was conducted over a period of 96 hours on the toxicity of m-cresol to three trout species. Among the fish species tested Salmo trutta (brown trout) was the most sensitive exhibiting a LC50 of 7.6 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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