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Diss Factsheets
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EC number: 204-435-9 | CAS number: 120-92-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The used protocol was the method published by the OECD. However, the purity of the test substance was not noted and the GLP were not mentioned.
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of the ocular-irritation potential of 56 compounds
- Author:
- Guillot JP, Gonnet JF, Clement C, Caillard L, Truhaut R
- Year:
- 1 982
- Bibliographic source:
- Food Chem Toxicol, 20, 573-582
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- occlusive application, surface area 4 cm²
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cyclopentanone
- EC Number:
- 204-435-9
- EC Name:
- Cyclopentanone
- Cas Number:
- 120-92-3
- Molecular formula:
- C5H8O
- IUPAC Name:
- cyclopentanone
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- - Source: Roucher SA, Couhé
- Weight at study initiation: about 2.5 kg
- Age at study initiation, housing, diet, water, acclimation period: data not available
ENVIRONMENTAL CONDITIONS (temperature, humidity, air changes, photoperiod) data not available
IN-LIFE DATES: data not available
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 72 hours (up to 7 or 14 days if pronounced irritation)
- Number of animals:
- 6
- Details on study design:
- TEST SITE:
- Area of exposure: 2 x 2 cm
- % coverage: data not available
- Type of wrap if used: gauze + patch
REMOVAL OF TEST SUBSTANCE: data not available
SCORING SYSTEM: according to Draize (1948)
PDII below 0.5, non-irritant; 0.5-3, slightly irritant; 3-5, moderately irritant; 5-8, severely irritant (AFNOR scale)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 3
- Max. score:
- 8
- Reversibility:
- no data
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
In the same conditions but with a semi-occlusive protocol, the PDII was 0.31.
No other information are available
Applicant's summary and conclusion
- Interpretation of results:
- other: Slightly irritating. Classified as irritant in the annex VI 3.2 of the CLP regulation 1272/2008
- Conclusions:
- Slightly irritating.
Classified as irritant in the annex VI 3.2 of the CLP regulation 1272/2008 - Executive summary:
In a primary dermal irritation study (Guillot JP, 1982), New Zealand White rabbits (6/group) were dermally exposed to 0.5 mL of cyclopentanone (purity unknown) undiluted for 4 hours to the flanks. Test sites were covered with an occlusive dressing for 4 hours. Animals then were observed for 3 days. Irritation was scored by the method of Draize.
In this study, Cyclopentanone was slightly irritating to the skin in rabbit.
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