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Diss Factsheets
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EC number: 245-442-7 | CAS number: 23128-74-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-09-26 to 1988-10-10
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- yes
- Remarks:
- , vehicle concentration 155 mg per liter test water, no analytical dose verification
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 10.0 g of the test substance were mixed with 398 mg alkylphenol-polyglykol-ether and made up to 25 mL with DMF
- Controls: Blank control with test medium only and vehicle control with 151 mg DMF and 4 mg alkylphenol-polyglykol-ether per liter water in the concentration used for the test concentration
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): alkylphenol-polyglykol-ether and DMF
- Stock solution: 10.0 g of the substance were mixed with 398 mg alkylphenol-polyglykol-ether and made up to 25 mL with DMF.
- Evidence of undissolved material (e.g. precipitate, surface film, etc): Yes. Small parts of the test substance were swimming at the surface of the test solution from the start of the test. A slight deposit was observed after 24h exposure. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrafish
- Source: West Aquarium / D-3422 Bad Lauterberg
- Length at study initiation (length definition, mean, range and SD): 24 mm (19-27 mm)
- Weight at study initiation (mean and range, SD): 0.12 g (0.05-0.17 g)
- Loading: 0.08 g/L
- Feeding during test: None
ACCLIMATION
- Acclimation period: 19 d
- Adaption: 24 hours / no food 24 hours prior to exposure - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Hardness:
- 180 mg CaCO3/L
- Test temperature:
- 23 ± 1°C
- pH:
- 8.1-8.4
- Dissolved oxygen:
- 85-100%
- Nominal and measured concentrations:
- Nominal: 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Glass aquaria of 20 liters filled with 15 liters (36/22/25 cm)
- Aeration: none
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): 1
- Biomass loading rate: 0.08 g/l
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated tap water (carbon filter)
- Intervals of water quality measurement: Daily
OTHER TEST CONDITIONS
- Photoperiod: Fluorescent light, 16 hours daily
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Mortality, Symptoms - Reference substance (positive control):
- no
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: None
- Mortality of control: None
- Other adverse effects control: None
- Abnormal responses: None
- Any observations (e.g. precipitation): Small parts of the test substance were swimming at the surface of the test solution from the start of the test. A slight deposit was observed after 24h exposure.
- Effect concentrations exceeding solubility of substance in test medium: Yes - Executive summary:
In a 96-h acute toxicity study, zebra-fish (Brachydanio rerio) were exposed to test item at nominal concentrations of 0 (control, solvent control) and 100 mg/L under static conditions. The 96-h LC50 was > 100 mg/L. The NOEC, based on mortality and sublethal effects, were ≥ 100 mg/L, respectively. Sublethal effects were not observed.
Reference
Description of key information
With high probability acutely not harmful to fish.
Key value for chemical safety assessment
Additional information
In a 96-h acute toxicity study, zebra-fish (Brachydanio rerio) were exposed to test item at nominal concentrations of 0 (control, solvent control) and 100 mg/L under static conditions. The 96-h LC50 was > 100 mg/L. The NOEC, based on mortality and sublethal effects, were ≥ 100 mg/L, respectively. Sublethal effects were not observed. It can be concluded that the test substance is not acutely toxic to fish in the range of solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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