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EC number: 274-641-1 | CAS number: 70516-41-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 March to 26 March 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study undertaken to internationally accepted guidelines but before the implementation of GLP regulations.
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.41 Method of testing primary irritant substances
- Deviations:
- not specified
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: reputable breeders
- Age at study initiation: 12 to 16 weeks old
- Weight at study initiation: 2.7 to 3.2 kg
- Housing: individually housed in metal cages with perforated floors
- Diet (e.g. ad libitum): free access to laboratory animal diet Grain Harvester 474 Special Rabbit Pellets
- Water (e.g. ad libitum): free access to tap water
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19°C
- Humidity (%): 30-70%
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12hrs dark / 12hrs light
IN-LIFE DATES: From: 23 March 1982 To: 26 March 1982 - Type of coverage:
- occlusive
- Preparation of test site:
- other: 10 cm square shaved then 2.5 cm square on the right side of the spine was abraded
- Vehicle:
- water
- Remarks:
- to moisten the substance
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.5 g
- Concentration (if solution): 1g/mL
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5mL of water - Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm square of abraded skin and 2.5 cm square of intact skin
- Type of wrap if used: gauze pads covered by "Elastoplast" elastic adhesive dressing backed with "Sleek" plaster
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the treatment sites were wiped to remove any residual test substance
- Time after start of exposure: 24 h
SCORING SYSTEM: Scoring was performed at 24 h and 72 h
Erythema and eschar formation:
0 No erythema
1 Very slight erythema (barely perceptible)
2 Well-defined erythema
3 Moderate to severe erytryema
4 Severe erythema (beet redness) to slight eschar formation (injuries in depth)
Oedema formation:
0 No oedema
1 Very slight oedema (barely perceptible) 1
2 Slight oedema (edges of area well-defined by definite raising)
3 Moderate oedema (raised approximately 1 mm)
4 Severe oedema (raised more than 1 millimeter and extending beyond the area of exposure) - Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 72h
- Score:
- 0
- Max. score:
- 0
- Irritant / corrosive response data:
- No dermal reactions were seen in any of the rabbits after 24 h exposure to S-205 during the 72 h observation period.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- S-205 is not considered to be an irritant to rabbit skin
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 to 29 March 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study undertaken to internationally accepted guidelines but before the implementation of GLP regulations.
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.42: Test for eye irritants
- Deviations:
- not specified
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: reputable
- Age at study initiation: 12 to 16 weeks old
- Weight at study initiation: 2.3 to 3.1 kg
- Housing: individually in metal cages with perforated floors
- Diet (e.g. ad libitum): laboratory animal diet ad libitum
- Water (e.g. ad libitum): tap water ad libitum
- Acclimation period: yes but no details
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19°C
- Humidity (%): 30 - 70%
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12 hrs dark / hrs light
IN-LIFE DATES: From: 22 March 1982 To: 29 March 1982 - Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 50mg of S-205 (corresponding to a volume of 0.1mL)
- Duration of treatment / exposure:
- S-205 was placed into the lower everted lid of one eye of each animal. The eyelids were then gently held together for one second before releasing. The eyes were not washed out.The contralateral eye remained untreated and served as a control.
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): not done
- Time after start of exposure: not applicable
SCORING SYSTEM: "Illustrated Guide for Grading Eye Irritation Caused by Hazardous Substances", Directorate for Engineering and Science.
u.S. Consumer Product Safety Commission, Washington D.C. 20207.
TOOL USED TO ASSESS SCORE: a handheld torch - Irritant / corrosive response data:
- Mild inflammation or a diffuse crimson-red colouration of the conjunctivae was seen in three rabbits. The eyes of two of these rabbits were normal by Day 2 and that of the third by Day 4. No ocular reactions were recorded in the remaining three rabbits.
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The eye irritation test for S-205 was negative
Reference
Rabbit Number and sex
|
Region of the eye
|
Day after instillation |
|||||
1 |
2 |
3 |
4 |
7 |
|||
2744 F
|
Cornea |
0 |
0 |
0 |
0 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
2 |
1 |
1 |
0 |
0 |
|
|
Chemosis |
0 |
0 |
0 |
0 |
0 |
|
2763M
|
Cornea |
0 |
0 |
0 |
0 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
0 |
0 |
0 |
0 |
0 |
|
|
Chemosis |
0 |
0 |
0 |
0 |
0 |
|
2765F
|
Cornea |
0 |
0 |
0 |
0 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
1 |
0 |
0 |
0 |
0 |
|
|
Chemosis |
0 |
0 |
0 |
0 |
0 |
|
2766F
|
Cornea |
0 |
0 |
0 |
0 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
||
Contjunctivae |
Redness |
0 |
0 |
0 |
0 |
0 |
|
|
Chemosis |
0 |
0 |
0 |
0 |
0 |
|
2767M
|
Cornea |
0 |
0 |
0 |
0 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
0 |
0 |
0 |
0 |
0 |
|
|
Chemosis |
0 |
0 |
0 |
0 |
0 |
|
2768F
|
Cornea |
0 |
0 |
0 |
0 |
0 |
|
Iris |
0 |
0 |
0 |
0 |
0 |
||
Conjunctivae |
Redness |
1 |
0 |
0 |
0 |
0 |
|
|
Chemosis |
0 |
0 |
0 |
0 |
0 |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
No other study available.
Justification for selection of eye irritation endpoint:
No other study available.
Justification for classification or non-classification
Study results show that S-205 is not an irritant to skin or eye. Therefore it will not be classified as an irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.