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Diss Factsheets
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EC number: 208-169-4 | CAS number: 513-79-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Method similar to guideline. No analytical dose verification.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The growth response of the green alga Chlorella vulgaris to combined divalent cation exposure.
- Author:
- Rachlin JW, Grosso A
- Year:
- 1 993
- Bibliographic source:
- Archives of Environmental Contamination and Toxicology 24:16–20.
- Reference Type:
- secondary source
- Title:
- CICAD 69, Cobalt and inorganic cobalt compounds
- Author:
- WHO
- Year:
- 2 006
Materials and methods
- Principles of method if other than guideline:
- 96 hour static test
- GLP compliance:
- no
Test material
- Reference substance name:
- Cobalt dichloride
- EC Number:
- 231-589-4
- EC Name:
- Cobalt dichloride
- Cas Number:
- 7646-79-9
- IUPAC Name:
- cobalt(2+) dichloride
- Details on test material:
- - Name of test material (as cited in study report): "chloride salt" of cobalt
- Analytical purity: no data
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Test solutions consisted of the modified Bristol's medium (pH 6.5) as control, or solutions of this medium containing the 96- h EC50 concentrations of the cations Cd, Co and Cu in the following combinations: Cd + Cu, Cd + Go, Cu + Co, and Cd + Cu + Co. Test soutions were made in modified Bristol's medium using the chloride salts of the cations in appropiate concentrations so that results are reported as concentrations of the cations alone.
Test organisms
- Test organisms (species):
- Chlorella vulgaris
- Details on test organisms:
- TEST ORGANISM
- Common name: Green alga
- Strain: UTEX 30
- Source (laboratory, culture collection): UTEX
- Age of inoculum (at test initiation): For experiments an inoculum of an exponential growing culture was used.
- Method of cultivation: static, grown in chelator free modified Bristol´s medium
ACCLIMATION
- Culturing media and conditions (same as test or not): yes
- Any deformed or abnormal cells observed: no data
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Test temperature:
- 19±1°C
- pH:
- 6.5 at test start
- Nominal and measured concentrations:
- 0.32, 0.56, 1.0 mg Co/L (nominal)
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type (delete if not applicable): closed
- Material, size, headspace, fill volume: erlenmeyer flask 125ml, fill volume 50ml
- Aeration: no
- Initial cells density: no data
- Control end cells density: no data
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
GROWTH MEDIUM
- Standard medium used: yes
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: chelateor-free modified Bristol medium
- Culture medium different from test medium: no
OTHER TEST CONDITIONS
- Sterile test conditions: yes
- Adjustment of pH: not during test
- Photoperiod: 16:8 L:D
- Light intensity and quality: Illumination was maintained at 280 foot candles (3.08 Klux, 7.84 W m-2)
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: hemocytometer
- Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 0.56 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Remarks:
- Co
- Basis for effect:
- growth rate
Any other information on results incl. tables
The EC50 was estimated by probit analysis: 0.522 ± 0.38 ppm (9.0 µM). This was confirmed in a series of runs in which test concentrations of cobalt at 0.56 ppm (9.5 µM) yielded a 50.7 % reduction in growth of the test Chlorella cultures.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.