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Diss Factsheets
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EC number: 210-431-8 | CAS number: 615-50-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test material was applied on shaved skin of rabbit for the determination of percutaneous toxicity.
Insufficient data provided to determine if a specific guideline was followed. - GLP compliance:
- no
- Remarks:
- pre GLP
- Test type:
- other: no data
- Limit test:
- yes
Test material
- Reference substance name:
- 2-methyl-p-phenylenediamine sulfate
- EC Number:
- 210-431-8
- EC Name:
- 2-methyl-p-phenylenediamine sulfate
- Cas Number:
- 615-50-9
- Molecular formula:
- C7H10N2.H2O4S
- IUPAC Name:
- 2-methylbenzene-1,4-diamine; sulfuric acid
- Reference substance name:
- 2-methyl-p-phenylenediamine sulphate
- EC Number:
- 228-871-4
- EC Name:
- 2-methyl-p-phenylenediamine sulphate
- Cas Number:
- 6369-59-1
- IUPAC Name:
- 2-methylbenzene-1,4-diamine sulfate
- Details on test material:
- - Name of test material (as cited in study report):
- Molecular formula (if other than submission substance):
- Name of test material: p-toluenediamine sulfate
- Molecular formula (if other than submission substance): Not reported
- Molecular weight (if other than submission substance): Not reported
- Smiles notation (if other than submission substance): Not reported
- InChl (if other than submission substance): Not reported
- Structural formula attached as image file (if other than submission substance): Not reported
- Substance type: Pure active substance
- Physical state: Not reported
- Stability under test conditions: Not reported
- Storage condition of test material: Not reported
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not reported
- Age at study initiation: Not reported
- Weight at study initiation: 1.7-2.5 kg
- Fasting period before study: Not reported
- Housing: Not reported
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum): Not reported
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS: Details on environmental condition is not provided in the report.
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: The test substance was applied in an oxidation-type hair dye base.
- Details on dermal exposure:
- TEST SITE: Details on test site are not provided in the report
REMOVAL OF TEST SUBSTANCE: Details on the ‘removal of test substance’ is not provided in the report.
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): Not reported
- Concentration (if solution): Not reported
- Constant volume or concentration used: Yes
- For solids, paste formed: Not reported
VEHICLE
- Amount(s) applied: 10 ml
- Concentration (if solution): Not reported
- Lot/batch no. (if required): Not reported
- Purity: Not reported - Duration of exposure:
- 24h
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 4-8 rabbits were tested per group (no data on sex).
- Control animals:
- not specified
- Details on study design:
- Details on the study design is not provided in the report
- Statistics:
- Not reported
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: Not reported
- Gross pathology:
- Not reported
- Other findings:
- Not reported
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The acute percutaneous LD50 of p-toluenediamine sulfate in New Zealand rabbits was greater than 5,000 mg/kg bw.
- Executive summary:
The acute percutaneous toxicity of p-toluenediamine sulfate was evaluated in a group of 4 -8 New Zealand rabbits (weight: 1.7-2.5 kg). The rabbits were shaved closely the day before the test substance was applied in 10 ml of an oxidation-type hair dye base. The period of application was 24 hours.
LD50 of p-toluenediamine sulfate was found to be greater than 5,000 mg/kg bw.
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