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EC number: 209-909-9 | CAS number: 597-82-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-05-13 to 2002-06-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- adopted on April 1984
- Deviations:
- yes
- Remarks:
- , no analytical dose verification.
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Due to the low water solubility of the test item, a supersaturated dispersion with a loading rate of 100 mg/L was prepared by weighing 30 mg of the test item into 300 mL test water. No auxiliary solvent or emulsifier was used. The test item was mixed into the test water as homogeneously as possible by ultrasonic treatment for 15 minutes and by intense stirring for 96 hours at room temperature to dissolve a maximum concentration of the test item in the dispersion. Then the supersaturated dispersion of the test item was filtered through a membrane fiber (Schleicher & Schuell, Type NC45, pore size 0.45 µm) just before the start of the test
- Controls: Blank: water.
- Stock solution: Due to the low water solubility of the test item, a supersaturated dispersion with a loading rate of 100 mg/L was prepared by weighing 30 mg of the test item into 300 mL test water.
- Evidence of undissolved material (e.g. precipitate, surface film, etc): none reported - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water Flea
- Strain: Daphnia magna Straus
- Source: RCC Ltd., Itingen, Switzerland
- Age at study initiation (mean and range, SD): 6-24 h
- Method of breeding: under conditions identical to those of the tests
- Pretreatment: At the start of the test, the used daphnids were 6 - 24 h old and were not first brood progeny
- Feeding during test: none - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg CaCO3/L
- Test temperature:
- 20 °C
- pH:
- 7.8 - 8.0
- Dissolved oxygen:
- 8.7 - 9.0 mg/L
- Nominal and measured concentrations:
- Nominal loading rate: 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beakers covered with glass plates filled with 50 mL solution per beaker
- Aeration: None during the test. The water was aerated with clean air for at least 24h before use.
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: < 1 daphnia per 2 mL of test solution
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted water according to the guideline.
- Intervals of water quality measurement: oxygen, pH, temperature daily
OTHER TEST CONDITIONS
- Photoperiod: Fluorescent light, 16 hours daily with a 30 minute transition period
- Light intensity: approx. 550 - 685 lux
EFFECT PARAMETERS MEASURED: Immobilization - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate, tested at least once a year to demonstrate satisfactory test conditions.
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- 100 mg/L loading rate WAF
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- 100 mg/L loading rate WAF
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Remarks:
- 100 mg/L loading rate WAF
- Basis for effect:
- mobility
- Details on results:
- - Effect concentrations exceeding solubility of substance in test medium: yes. No effects were observed at a loading rate of 100 mg/L which exceeds the solubility of the test substance. It can be concluded that the test substances causes no toxic effects in the range of solubility.
- Mortality of control: 0 % mortality was observed in the control. - Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance is not acutely harmful to aquatic invertebrates up to the limit of solubility in water.
Reference
Description of key information
The test substance is not acutely harmful to aquatic invertebrates up to the limit of solubility in water.
Key value for chemical safety assessment
Additional information
Three studies investigating the short-term toxicity of O,O,O-triphenyl phosphorothioate to aquatic invertebrates are available.
The key study was performed according to GLP and OECD guideline 202 using Daphnia magna as test organism (RCC 2002). Daphnids were exposed to control and saturation concentration (undiluted filtrate of the test item with a nominal loading rate of 100mg/L) for 48h. Mortality/immobilization and sublethal effects were observed daily. No effects were observed at saturation concentration (undiluted filtrate of the test item with a nominal loading rate of 100mg/L). Thus, the 48h-EL50 was determined to be higher than saturation concentration. It can be concluded that the test substance causes no toxic effects in the range of solubility.
In a supporting study conducted according to OECD guideline 202 (Ciba-Geigy 1996) with O,O,O-triphenyl phosphorothioate in a lower purity (purity > 25%) the 48h-EL50 based on mobility of the test animals was higher than the saturation concentration (100 mg/L loading rate WAF).
In addition, a non-GLP study on acute toxicity to Daphnia is available (Ciba-Geigy 1988). The acute toxicity of the test item to Daphnia magna was studied under static conditions over an exposure time of 24h. Daphnids were exposed to control, solvent control, and test item at nominal concentration of 10, 18, 32, 58 and 100 mg/L for 24 hr. Mortality/immobilization and sublethal effects were recorded daily. The EC50 was determined to be 49 mg/L, and thus above the solubility limit. Undissolved test material was observed from the beginning of the test. Therefore, this study is disregarded due to major methodological deficiencies and insufficient exposure duration.
Based on the available data, it can be concluded that O,O,O- triphenyl thiophosphate is not acutely toxic to aquatic invertebrates up to the limit of solubility in water.
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