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EC number: 203-957-4 | CAS number: 112-31-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010-08-24 to 2010-09-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Deviations:
- yes
- Remarks:
- A first first using UV detection as foreseen in the study plan gave too weak a signal. Therefore the test was repeated using RI detector. Only the results of the second test are reported.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- yes
- Remarks:
- as above
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC estimation method
- Media:
- soil/sewage sludge
- Specific details on test material used for the study:
- - Names of test material (as cited in study report): Aldehyde C10 decyclic food grade; decanal
- Substance type: Colourless liquid
- Physical state: Liquid
- Purity test date: No data
- Lot No: VE00097618
- Expiration date of the lot: 2011-06-01
- Stability under test conditions: No data
- Storage condition of test material: No data - Radiolabelling:
- no
- Test temperature:
- 35 °C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: HPLC equipment - a Perkin Elmer (series 200) HPLC system comprising (1) a high pressure pump, (2) an autosampler (3) a column compartment (4) a variable wavelength detector
- Analytical (guard) column: 150 mm height × 4.6 mm diameter Nucleodor 100-5 CN-RP (Macherey-Nagel), serial No. N8030929, batch No. 3034
DETERMINATION OF DEAD TIME
- Method: by inert substance (formamide) which is not retained by the column.
REFERENCE SUBSTANCES
- Formamide (CAS No. 75-12-7, logKoc="dead time", conc. = 4.0 g/L, 99.6 % pure)
- 2-Nitrobenzamide (CAS No. 610-15-1, logKoc = 1.45, conc. = 0.20 g/L, 98.7 % pure)
- Methyl benzoate (CAS No. 93-58-3), logKoc = 1.80, conc. = 0.20 g/L, 99.9 % pure)
- Naphthalene (CAS No. 91-20-3, logKoc =2.75, conc. = 0.05 g/L, 99.9 % pure)
- 1,2,3-Trichlorobenzene, (CAS No. 87-61-6, logKoc =3.16, conc. = 0.20 g/L, 99.9 % pure)
- Phenanthrene (CAS No. 85-01-8, logKoc =4.09, conc. = 0.10 g/L, 99.2 % pure)
- 4,4'-DDT (CAS No. 50-29-3, logKoc =5.63, conc. = 0.20 g/L, 96.0 % pure)
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 12.5 mg in 50 µL methanol/water 55/45 % v/v mixture
- Calibration mix a: 2 mL each of stock solutions of formamide, methyl benzoate, naphthalene and phenantrene, enough ultrapure water to obtain a solvent composition similar to the mobile phase (6.55 mL).
- Calibration mix b: 2 mL each of stock solutions of 2-nitrobenzamide, 1,2,3-trichlorobenzene, and 4,4'-DDT, enough ultrapure water to obtain a solvent composition similar to the mobile phase (4.91 mL).
- Injection sequence of solutions: calibration a, calibration b, test, test, calibration a, calibration b.
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k': Calculated using the equation k = tR/t0 - 1,
-- where tR = retention time and t0 = "dead time", i.e. retention time of formamide
- Retention times were measured.
- Determination of the log Koc value: Linear regression parameters of the relationship log Koc = f(log k) was calculated from the data obtained from the calibration mixture.
-- From this, the log Koc of the test substance was determined from its measured capacity factor. - Analytical monitoring:
- not specified
- Type:
- log Koc
- Value:
- 2.9
- Temp.:
- 35 °C
- Details on results (HPLC method):
- - For details of results and calculations please see Appendix 1 (attached).
- The results are graphed in Appendix 2 (attached).
- Chromatogram of the reference substances is attached (Appendix 3)
- Chromatogram of the test substance is attached (Appendix 4) - Validity criteria fulfilled:
- yes
- Conclusions:
- The adsorption coefficient of the test substance was assessed according to OECD guideline 121. The chromatograms of the test substance show one peak at an average retention time of 4.03 minutes, corresponding to an adsorption coefficient (log value) of 2.9. Therefore the adsorption coefficient (Koc) of decanal is log Koc 2.9.
Reference
The determination was performed at 35 °C (temperature of the column) but the value obtained can be considered to represent the value at an unspecified, probably ambient temperature since no mention is made in the guidelines of the temperature at which the tabulated reference substances log Koc values were determined. Adsorption coefficients of the test and reference substances are assumed to vary with temperature in the same way.
Description of key information
Log Koc 2.9 (OECD 121)
Key value for chemical safety assessment
- Koc at 20 °C:
- 794
Additional information
The adsorption coefficient of the test substance was assessed according to OECD guideline 121. The chromatograms of the test substance show one peak at an average retention time of 4.03 minutes, corresponding to an adsorption coefficient (log value) of 2.9. Therefore the adsorption coefficient (Koc) of decanal is log Koc 2.9, equivalent to a Koc of 794.
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