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Diss Factsheets
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EC number: 209-143-5 | CAS number: 556-88-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1990
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: not reported
- Principles of method if other than guideline:
- The aqueous solubility was determined by suspending 0.1 g of nitroguanidine in each of three centrifuge tubes containing 25 ml of water; the tubes were rotated for 4 d in a closed chamber at 25 °C and then centrifuged at 10000 rpm for 60 min; the nitroguanidine was analyzed directly in the aqueous fraction by HPLC.
- GLP compliance:
- not specified
- Type of method:
- other: not mentioned in detail
- Specific details on test material used for the study:
- Test substance supplier: Aldrich Chemical Co
Water content 25% - Key result
- Water solubility:
- 2.6 g/L
- Conc. based on:
- test mat. (total fraction)
- Temp.:
- 25 °C
- Remarks on result:
- other: pH value was not specified
- Conclusions:
- Nitorguanidine is soluble (1000-10000 mg/l) in water.
- Executive summary:
The water solubility of nitroguanidine was determined by suspending 0.1 g of nitroguanidine in each of three centrifuge tubes containing 25 ml of water; the tubes were rotated for 4 d in a closed chamber at 25 °C and then centrifuged at 10000 rpm for 60 min; the nitroguanidine was analyzed directly in the aqueous fraction by HPLC. Six experiments were conducted at 25 °C. The water solubility was measured to be 2.6 +-0.1 g/l at 25 °C.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- September 1982 - October 1982
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Remarks:
- This is a review of environmental fate, although comprehensive and useful for extracting physico-chemical data and general fate information.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: not reported
- Principles of method if other than guideline:
- Information on physico-chemical properties was taken from "Encyclopedia of Explosives and Related Items. PATR2700 Vol. 6. Picatinny Arsenal, Dover, NJ (1974)"
- GLP compliance:
- not specified
- Type of method:
- other: not mentioned, secondary literature
- Specific details on test material used for the study:
- Test substance supplied by Sunflower AAP
- Key result
- Water solubility:
- 4.4 g/L
- Conc. based on:
- test mat. (total fraction)
- Temp.:
- 25 °C
- Remarks on result:
- other: pH value was not specified
- Water solubility:
- 83.5 g/L
- Conc. based on:
- test mat. (total fraction)
- Temp.:
- 100 °C
- Remarks on result:
- other: pH value was not specified
- Conclusions:
- Nitorguanidine is soluble (1000-10000 mg/l) in water.
- Executive summary:
The study is a data base assessment of environmental fate aspects of nitroguanidine including information to water solubility. The information was taken from "Encyclopedia of Explosives and Related Items. PATR2700 Vol. 6. Picatinny Arsenal, Dover, NJ (1974)". The water solubility is 4.4 g/l at 25 °C and 83.5 g/l at 100 °C.
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: not reported
- Principles of method if other than guideline:
- Secondary literature, details on methods not reported.
- GLP compliance:
- not specified
- Type of method:
- other: not mentioned: secondary literature
- Specific details on test material used for the study:
- Test substance supplier not specified.
- Key result
- Water solubility:
- 3.4 g/L
- Conc. based on:
- test mat. (total fraction)
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not specified
- Conclusions:
- Nitorguanidine is soluble (1000-10000 mg/l) in water.
- Executive summary:
The information is extracted from secondary literature published by the Environmental Agency R&D Dissemination Centre. The following values from different sources are stated: 2.6 (+-0.1) g/l at 25 °C, 4.2 g/l at 25 °C, 4.4 g/l at 25 °C, and 90.0 g/l at 100 °C. An average aqueous solubility of 3.4 g/l at 25 °C is recommended for use.
Referenceopen allclose all
Six experiments were conducted at 25 °C.
The information was taken from "Encyclopedia of Explosives and Related Items. PATR2700 Vol. 6. Picatinny Arsenal, Dover, NJ (1974)".
The following values from different sources are stated: 2.6 (+-0.1) g/l at 25 °C, 4.2 g/l at 25 °C, 4.4 g/l at 25 °C, and 90.0 g/l at 100 °C.
Description of key information
There are four different literature sources available for the weight of evidence.
All results indicate that nitroguanidine is soluble in water (1000-10000 mg/l).
Key value for chemical safety assessment
- Water solubility:
- 3 g/L
- at the temperature of:
- 20 °C
Additional information
The study of AlzChem is chosen for robust study summary because of the reference temperature of 20 °C instead of 25 °C as well as the fact as the information source is the data owner (information source material safety data sheet).
According to four different literature sources nitroguanidine is soluble (1000-10000 mg/l) in water:
- 3.0 g/l at 20 °C (according to AlzChem, 2008)
- 2.6, 3.4, and 4.4 g/l at 25 °C (according to Haag et al., 1990, Environment Agency R&D Dissemination Centre, and Kenyon, 1982, respectively)
- 83.5 g/l at 100 °C (according to Kenyon, 1982)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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