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EC number: 272-805-7 | CAS number: 68912-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 June 2000 - 30 June 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl propionate
- EC Number:
- 272-805-7
- EC Name:
- 3a,4,5,6,7,7a-hexahydro-4,7-methano-1H-indenyl propionate
- Cas Number:
- 68912-13-0
- Molecular formula:
- C13H18O2
- IUPAC Name:
- Reaction mass of 3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-5-yl propionate and 3a,4,5,6,7,7a-hexahydro-1H-4,7-methanoinden-6-yl propionate
- Test material form:
- liquid
1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Charles Rover, Germany
- Weight at study initiation: 3.2 kg - 3.3 kg
- Housing: Individually caged in PPO cages (floor area 2576 cm2) with perforated floor
- Diet: Complete rabbit diet 'Altromin 2123' was available ad libitum
- Water: water (acidified with hydrochloric acid to pH 2.5 in order to prevent microbial growth) was available ad libitum
- Acclimation period: at least on week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C +/- 3°C
- Humidity (%): 55% +/- 15%
- Air changes (per hr): 10 times per hour
- Photoperiod (hrs dark / hrs light): cycle of 12 hours light and 12 hours dark
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- concentration: 100%
- 0.1 ml test material was placed in one eye of the rabbits and the lids were held together for 1 second - Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- - day before testing (both eyes of animals)
- 1, 24, 48 and 72 hours after treatment - Number of animals or in vitro replicates:
- four female rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsing with 20 ml 0.9% sodium chloride solution
- Time after start of exposure: 24 hours
SCORING SYSTEM: see table below. When Fluorescein was used the cornea reactions were scored both before and after the instillation of Fluorescein.
TOOL USED TO ASSESS SCORE:
- hand held inspectio lamp fitted with white and UV-light and magnifying glass woth 2x magnification
- examination was performed before and after instillation of fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: 1, 3, and 4
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- One hour after application one animal showed a diffuse, crimson red conjunctiva with individual vessels not easily discernible, a swelling above normal and a discharge different from normal. Another animal showed some conjunctival vessels definitely injected and a sweling above normal. The other two animals showed some conjunctival vessels definitely injected, a swelling above normal and a discharge different from normal.
24 hours after application of the test material some conjunctival vessels definitely injected were observed in three animals. One animal was free of signs of eye irritation.
48 hours and 72 hours after application all four animals were free of signs of irritation.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not an eye irritant
- Remarks:
- according to EU CLP (EC 1272/2008 and its amendments)
- Conclusions:
- In an eye irritation test in accordance with OECD405, very slight signs of irritation were observed on the treated eyes. All effects were fully reversible after 48 hours. The test material was not irritating to the eyes under the conditions of this test.
- Executive summary:
The potential of Cyclaprop to cause eye irritation was determined according to OECD guideline 405. Four New Zealand White female rabbits were exposed to 0.1 ml of the undiluted test article in one of the eyes. The other eye served as a control. The eyes were examinated and the changes graded according to a numerical scale one hour, 24, 48, 72 hours after dosing. The animals showed very slight signs of irritation on the treated eyes. Mean corneal opacity, chemosis, and iris scores at the 24, 48, and 72 hour time point were 0 in all animals. Mean conjunctivae score was 0.33 in three animals and 0 in one animal. The effects seen in the one animal was reversible within one day. It is concluded that Cyclaprop is not an eye iritant.
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