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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Documentation is insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Principles of method if other than guideline:
Mice were exposed once to the test substance by intraperitoneal application.
GLP compliance:
no
Remarks:
study performed prior to implementation of GLP

Test material

Constituent 1
Chemical structure
Reference substance name:
4-tert-butylcyclohexanol
EC Number:
202-676-4
EC Name:
4-tert-butylcyclohexanol
Cas Number:
98-52-2
Molecular formula:
C10H20O
IUPAC Name:
4-tert-butylcyclohexan-1-ol

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
CMC (carboxymethyl cellulose)
Remarks:
0.5% in water
Details on exposure:
Concentration of test substance in vehicle: 6-20% (suspension)
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 700 mg/kg bw
Based on:
test mat.
Clinical signs:
Dyspnea, apathy, tremor, clonic convulsions, atony, exsiccosis, prone position, and partially opisthotonos were noted.
Gross pathology:
Slight intraabdominal test substance residues and accumulations were observed.

Applicant's summary and conclusion

Conclusions:
A single intraperitoneal application of 4-tert-butylcyclohexanol in mice resulted in an LD50 value of 700 mg/kg bw. Only limited information on test method (test animals, applied concentrations, mortality etc.) is provided and thus documentation is insufficient for assessment.