Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 913-888-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- October 17-31, 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP-compliant and according to OECD 402 in rat. Purity test substance unknown.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Ammonium dihydrogenorthophosphate
- EC Number:
- 231-764-5
- EC Name:
- Ammonium dihydrogenorthophosphate
- Cas Number:
- 7722-76-1
- Molecular formula:
- H3N.H3O4P
- IUPAC Name:
- ammonium dihydrogen phosphate
- Details on test material:
- - Analytical purity: Available Phosphoric Acid – 52.25% Total Nitrogen – 11.38%
- Stability under test conditions: Test substance is expected to be stable for the duration of testing
- Storage condition of test material: July 5, 2001
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Received from Ace Animals, Inc., Boyertown, PA on October 10, 2000
- Age at study initiation: Young adult (8-9 weeks)
- Weight at study initiation: males 210-233 grams and females 180-190 grams at experimental start
- Housing: The animals were singly housed in suspended stainless steel caging with mesh floors which conform to the size recommendations in
the most recent Guide for the Care and Use of Laboratory Animals DHEW (NIH). Litter paper was placed beneath the cage and was changed at least
three times per week.
- Diet (e.g. ad libitum): Purina Rodent Chow #5012
- Water (e.g. ad libitum): Filtered tap water was supplied ad libitum by an automatic water dispensing system.
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-22°C
- Photoperiod (hrs dark / hrs light): 12 hour light/dark cycle
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: moistened
- Details on dermal exposure:
- Prior to application, the test substance was ground in a coffee mill and moistened to achieve a dry paste by preparing an 85% w/w mixture.
In order to insure adequate contact with the skin, the sample was applied as a dry paste, and administered as an 85% w/w mixture
in distilled water.
MAP was applied to the shaved intact skin on the back of each rat and covered with gauze pads.
After 24 hours the pads were removed and the test areas gently wiped with water. - Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg of bodyweight
(85% w/w mixture) Five thousand milligrams per kilogram of bodyweight of the test substance was moistened with distilled water and applied to the
skin of ten healthy rats for 24 hours. Individual doses were calculated based on the initial bodyweights, taking into account the concentration
of the test mixture. - No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- Prior to application, the test substance was ground in a coffee mill and moistened to achieve a dry paste by preparing an 85% w/w mixture. In order
to insure adequate contact with the skin, the sample was applied as a dry paste, and administered as an 85% w/w mixture
in distilled water.
- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: initial and again on days 7 and 14
- Necropsy of survivors performed: YES
- Other examinations performed: Individual bodyweights of the animals were recorded prior to test substance application (initial) and again on Days 7 and 14 (termination). The animals were observed for mortality, signs of gross toxicity, and behavioral changes at 1 and 3 hours after application
and at least once daily thereafter for 14 days. Observations included gross evaluation of skin and fur, eyes and mucous membranes, respiratory,
circulatory, autonomic and central nervous systems, somatomotor activity and behavior pattern. Particular attention was directed to observation of
tremors, convulsions, salivation, diarrhea and coma. - Statistics:
- No data.
Results and discussion
- Preliminary study:
- No data.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- All animals survived.
- Clinical signs:
- other: Animals appeared active and healthy throughout the test.
- Gross pathology:
- MALES: All tissues/organs No gross abnormalities
FEMALES: All tissues/organs No gross abnormalities - Other findings:
- No data.
Any other information on results incl. tables
None.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No signs of toxicity were observed. LD50 > 5000 mg/kg
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.