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Diss Factsheets
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EC number: 430-750-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
In the available skin and eye irritation/ corrosion studies in rabbits performed according to OECD Guidelines 404 and 405 respectively, the test substance Urea 4 showed no irritation/ corrosion effects.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin
An in vitro skin irritation was not conducted because adequate data from an in vivo skin irritation study are available.
The test substance Urea 4 was tested for its irritation/ corrosion properties in a study performed according to EU Method B.4, OECD Guideline 404 and EPA OPPTS 870.2500. The test substance was applied to one site of the clipped back of 3 rabbits at a dose of 0.5 g per application site while the untreated side served as control. The application site was covered with a semi - occlusive bandage for a 4 hour - contact/ exposure time. Observations were recorded and compared to the control sites, 1, 24, 48 and 72 hours after removal of the patch. The test item showed no irritant/ corrosive effects on the intact skin within 72 hours after removal of the test item. No other clinical signs of toxicity were observed. Under the conditions of the study, the test substance was considered to have no irritation/corrosive properties.
Eye
An in vitro eye irritation was not conducted because adequate data from an in vivo eye irritation study are available.
The test item Urea 4 was tested for its eye irritation/ corrosion properties according to EU Method B.5, OECD Guideline 405 and EPA OPPTS 870.2400. In the available study the test item was applied to the lower conjunctival sac of one eye of 3 rabbits at a dose of 0.1 g per application site and it was not rinsed thereafter. The untreated eye served as control. Observations were calculated and compared to controls 1, 24, 48 and 72 hours after application of the test item. Application of the test item caused minimal blepharospasm in all animals immediately after application and 1 hour after application a slight erythema of the conjunctivae was visible. No signs of irritation were visible at the 24 hours reading in all of the 3 test animals. No corneal lesions were found upon fluorescein examination at the 72 h reading. For all three animals, the mean cornea and iris scores were 0 and the conjunctivae scores for redness and chemosis were 0.78. No corrosion effect were observed. Under the study conditions the test item was considered to have no irritation and no corrosive effects to eyes of rabbits.
Justification for selection of skin
irritation / corrosion endpoint:
GLP and guideline conform study
Justification for selection of eye irritation endpoint:
GLP and guideline conform study
Justification for classification or non-classification
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
Based on the available experimental test data, the test substance is not considered to be classified for skin irritation/corrosion or eye irritation under Regulation (EC) No 1272/2008, as amended for the eighteenth time in Regulation (EU) 2022/692.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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