Registration Dossier
Registration Dossier
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EC number: 219-553-6 | CAS number: 2461-15-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Concerning the physico-chemical properties of 2-ethylhexyl glycidyl ether, i.e., low molecular weight (189.26) and log Pow value (3.83), absorption of 2-ethylhexyl glycidyl ether is expected to mainly occur via dermal and oral route, with very limited potential for inhalation absorption. After absorption, 2-ethylhexyl GE is expected to be mainly detoxified though chemical or enzymatic hydrolysis by epoxide hydratase and conjugation with GSH. In addition, 2-ethylhexyl GE can be metabolized to adduct with some proteins. Metabolites are distributed in blood cells, thyroid, liver and kidney. Animal data suggest that 2-ethylhexyl GE may be excreted mainly via urine or (to a smaller extent) by feces, in form of metabolites that result from conjugation with GSH, or from the epoxide hydrolysis pathway and parent compound. In addition, excretion of metabolite after oxidative de-alkylation has been demonstrated.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
See detailed toxicokinetic assessment in attached report.
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