Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 279-815-0 | CAS number: 81782-77-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key study acute dermal toxicity: No adverse effects observed, LD50 > 5000 mg/kg, Levenstein 1975 (3,7-dimethyl-4,6-octadien-3-ol)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The data is taken from an abstract of an internal company report with incomplete reporting on the method; it is not possible to assess the accuracy of the information presented.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- Principles of method if other than guideline:
- Mice were exposed to 1000, 2000, 4000 or 8000 test material via the oral route. Ten mice were exposed per dose level and the rate of mortality was recorded at each.
- GLP compliance:
- no
- Test type:
- other: not reported
- Limit test:
- no
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Weight at study initiation: 17-22g
- Route of administration:
- oral: unspecified
- Vehicle:
- other: Gum Arabic
- Doses:
- 1000, 2000, 4000 and 8000 mg/kg
- No. of animals per sex per dose:
- 10 animals per dose
- Control animals:
- not specified
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 8 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 > 8000 g/kg
- Mortality:
- 3/10 animals died at the highest dose administered 8000.No other mortalities were recorded.
- Interpretation of results:
- not classified
- Remarks:
- Migrated informationCriteria used for interpretation of results: EU
- Conclusions:
- The LD50 of the test material was recorded to be > 8000 mg/kg in mice.
- Executive summary:
In a non GLP compliant study the oral toxicity of the test material was determined by exposing mice to 100, 2000, 4000 or 8000 test via an unspecified oral route. Ten mice were exposed per dose and the rate of mortality was recorded. The LD₅₀ was determined to be > 8000 mg/kg.
Reference
No further information on results is available.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
Oral Toxicity
In the key study (Levenstein, 1972) the acute toxicity of the test material was determined in a limit test performed at 5000 mg/kg (5 mL/kg). The study was performed to sound scientific principles with limited but a sufficient level of reporting to assess the quality of the submitted data. The method followed was similar to the current standardised guideline OECD 402 with deviations not thought to affect the validity of the results presented. Four rabbits were exposed to the test material under an occlusive dressing for 24 hours. Animals were exposed on the back of each animal to intact and abraded. Abraded skin was prepared by making epidermal abrasions every 2 -3 cm, longitudinally, over the clipped area. Post exposure the dressing was removed, the dermal reaction scored and the site thoroughly wiped to remove any remaining test material. Animals were then returned to their cages and observations continued for 14 days. Under the conditions of the test, no mortality was observed in the limit test. All animals showed a moderate erythema after 24 hour exposure, similar reactions observed on both the intact and abraded skin.
Dermal Toxicity
The acute dermal toxicity of the test material has been assessed by read-across to structural, mechanistically similar substance using the OECD QSAR Toolbox to predict the dermal LD50 of 3030 mg/kg. QSAR predicting is attached within the endpoint.
Predicted LD50 in rabbits after dermal application is 3030 (1790 - 5150) mg/kg.
Inhalation Toxicity
In line with Column 2, point 8.5.2, Annex VIII of Regulation 1907/2006, an acute inhalation study does not need to be performed as the substance has a low vapour pressure and the use of this substance will not result in aerosols, particles or droplets of an inhalable size, so exposure to humans via the inhalatory route will be unlikely to occur. The acute toxicity endpoint has been addressed by assessing the toxicity via the oral and dermal routes, which is more appropriate when considering the properties of this substance.
Justification for classification or non-classification
According to the criteria outlined in Regulation 1272/2008 and Directive 67/548/EEC, the test material does not meet the criteria for classification for acute toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.