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Registration Dossier
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Diss Factsheets
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EC number: 203-685-6 | CAS number: 109-59-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted prior to GLP and test guidelines, but sufficient data is available for interpretation of results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- one drop of the liquid was admintered into the conjunctival sacs of 6 rabbits eyes, three of which were promptly washed.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-(propyloxy)ethanol
- EC Number:
- 220-548-6
- EC Name:
- 2-(propyloxy)ethanol
- Cas Number:
- 2807-30-9
- Molecular formula:
- C5H12O2
- IUPAC Name:
- 2-propoxy-1-ethanol
- Details on test material:
- - Name of test material (as cited in study report): 2-)Propoxyethanol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 1 drop/eye
- Duration of treatment / exposure:
- one drop of the liquid was admintered into the conjunctival sacs of 6 rabbits eyes, three of which were promptly washed.
- Observation period (in vivo):
- no data
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- one drop of the liquid was admintered into the conjunctival sacs of 6 rabbits eyes, three of which were promptly washed.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: observation
- Remarks on result:
- probability of moderate irritation
- Remarks:
- moderate to strong irritant
- Irritant / corrosive response data:
- The ocular irritancy of the compound was determined using a Standardized test administration of' one drop of liquid to the conjunctival sacs of 6
rabbit eyes, three of which were promptly washed. The compound was moderate to strong eye irritant causing slight to severe erythema and slight to moderate edema of the conjunctivae, iritis and staining of adnexae and cornea. Some degree of corneal opacity was seen in all eyes tested . All signs resolved by 14 days. Prompt irritation had a slight palliative effect.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- Based on the results of the study the material was moderately toxic to eyes of rabbits. According to the EU CLP regulations (GHS Criteria), the substance would be classified as a Category 2
- Executive summary:
The ocular irritancy of the compound was determined using a Standardized test administration of' one drop of liquid to the conjunctival sacs of 6 rabbit eyes, three of which were promptly washed. The compound was moderate to strong eye irritant causing slight to severe erythema and slight to moderate edema of the conjunctivae, iritis and staining of adnexae and cornea. Some degree of corneal opacity was seen in all eyes tested . All signs resolved by 14 days. Prompt irritation had a slight palliative effect.
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