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EC number: 237-335-9 | CAS number: 13752-51-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Federal Hazards Substances Act (Revised Federal Register Sept 17 1964)
- GLP compliance:
- no
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- EC Number:
- 237-335-9
- EC Name:
- 4-[(morpholinothio)thioxomethyl]morpholine
- Cas Number:
- 13752-51-7
- Molecular formula:
- C9H16N2O2S2
- IUPAC Name:
- morpholin-4-yl morpholine-4-carbodithioate
- Details on test material:
- Good-Rite® 3030x18 (Cure-Rite® 18); purity: not noted
Constituent 1
Test animals
- Species:
- rabbit
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- physiological saline
- Details on dermal exposure:
- Dose was applied to the abdominal skin area from which the fur had been previously removed with electric clippers. The abdominal skin area of two rabbits in each group was abraded by making a series of longitudinal minor epidermal incisions, sufficiently deep enough to penetrate the epidermis but not to induce bleeding. The two remaining rabbits in each group remained intact.
- Duration of exposure:
- 24 hours initial dosing, followed by 14 days observation period.
- Doses:
- 1.00, 2.15, 4.64 and 10.0 gm/Kg of body weight.
- No. of animals per sex per dose:
- not specified.
- Control animals:
- no
- Details on study design:
- Observation period after administration: 14 days.
Gross necropsies conducted on surviving animals after 14 days: yes.
Starting body weights of all rabbits: 2328 - 2834 gm.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: no confidence limits were calculated during this study
- Mortality:
- 1 rabbit (Rabbit No. 4) died on day 8 of the observation period, the remaining animals survived to the end of the study.
- Clinical signs:
- other: other: Observation of Rabbit 4 showed slight emaciation, nasal discharge and wheezing noted on the 6th and 7th post-exposure day. Death followed on day 8. For the remaining animals, a few exhibited slight ataxia at completion of the exposure period only.
- Gross pathology:
- rabbit number 4 which died showed congested lungs, kidneys and adrenals; abcesses diffusely scattered throughout the lungs; depleted body fat stores; and autolytic alterations.
Gross necropsies performed at termination revealed depleted body fat stores in one rabbit. No other significant pathological alterations were noted. - Other findings:
- when the binders where removed after the 24 hour exposure period, varying amounts of moist sample were present on the binders and abdomens of the rabbits, indication incomplete dermal absorption of the applied material.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Regulations for the Enforcement of the Federal Hazardous Substances Act (revised, Federal Register, September 17, 1964)
- Conclusions:
- The acute dermal LD50 for albino rabbits was found to be greater than 10.0 g/Kg of body weight.
- Executive summary:
Four groups consisting of four rabbits each were exposed to the test substance by dermal exposure at 1.0, 2.15, 4.64 and 10 g/kg bodyweight for a period of 24 hours. At the end of the exposure period, the test substance was washed off, and the test animals were observed for mortality, clinical signs and signs of dermal irritation for a period of 14 days after exposure. At the end of the observation period, all test animals were sacrificed and post mortem examinations were performed.
One rabbit (Rabbit 4) in the 1.0 mg/kg group was found dead on day 8. No other deaths occurred in the test animals during the exposure or observation periods. Observation of Rabbit 4 showed slight emaciation, nasal discharge and wheezing noted on the 6th and 7th post-exposure day. Death followed on day 8. For the remaining animals, a few exhibited slight ataxia at completion of the exposure period only. Emaciation in four rabbits and a purulent nasal discharge in several animals were noted. The surviving rabbits exhibited normal appearance and behavious throughout the study.
The acute lethal dermal dose to rabbits of Cure-rite 18 was found to be greater than 10.0 g/kg bodyweight.
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