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EC number: 203-607-0 | CAS number: 108-69-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guideline for 28-day repeat dose toxicity testing of chemicals (Japan)Japanese
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- 3,5-Dimethylanilin
- IUPAC Name:
- 3,5-Dimethylanilin
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28
- Frequency of treatment:
- 1 per day
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
10
Basis:
no data
- Remarks:
- Doses / Concentrations:
60
Basis:
no data
- Remarks:
- Doses / Concentrations:
360
Basis:
no data
- No. of animals per sex per dose:
- 6 and 12 (0,360 mg/kg)
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 10 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Abstract from original report from JECDB-Database 2012:
3,5-Dimethylaniline was studied for oral toxicity in rats in a 28-day repeat dose toxicity test at doses of 0, 10, 60 and 360 mg/kg.
Cyanosis, blanching, salivation, exophthalmos and staggering gait were observed in males and/or females of the 360 mg/kg group, along with decreased body weight gain and food consumption. Urinalysis showed increase in urine volume, increases in sodium, potassium and chloride excretion, and decreases in osmotic pressure and specific gravity in males and females of the 360 mg/kg group. Hematological examination showed increases in methemoglobin and reticulocytes, and decreases in erythrocytes, hemoglobin and hematocrit in males and females of the 60 mg/kg and 360 mg/kg groups. Further, increase in leukocytes in males and females of the 360 mg/kg group, increase in segmented neutrophils in males of the 360 mg/kg group, and shortening of activated partial thromboplastin time in females of the 360 mg/kg group were detected. Blood chemical examination showed increases in total bilirubin, GOT, GPT, phospholipids and inorganic phosphorus in males and females of the 360 mg/kg group. Further, decreases in potassium and chloride in males of the 360 mg/kg group, and increases in total cholesterol and calcium in females of the 360 mg/kg group were detected. Spleen weights were increased in males and females of the 60 mg/kg and 360 mg/kg groups, and the thyroid, liver and kidney weights in both sexes of the 360 mg/kg group. In addition, the testis weights were increased in the 360 mg/kg group. Histopathologically, hemosiderin deposits in the liver and spleen, and extramedullary hematopoiesis of the spleen were apparent in males and females of the 60 mg/kg and 360 mg/kg groups. Hemosiderin deposits in the kidney and extramedullary hematopoiesis in the liver were also observed in males and females of the 360 mg/kg group. Hypertrophy of hepatocytes and follicular cells in the thyroid was noted in males of the 60 mg/kg group and males and females of the 360 mg/kg group. In the kidney, papillary necrosis was observed in males and females of the 360 mg/kg group, and hyaline droplets in the tubular epithelium in males of the 360 mg/kg group. In the recovery test, papillary necrosis in the kidney, and hemosiderin deposit in the liver, spleen and kidney persisted in males and females of the 360mg/kg group. However, the other changes observed during the administration period demonstrated recovery. The NOEL is considered to be 10 mg/kg/day for males and females.
3,5-Dimethylaniline induced structural chromosomal aberrations in CHL/IU cells at the highest concentration (900μg/ml) after a 6 hr short-term treatment with and without exogenous metabolic activation. Polyploidy was not induced under the conditions of the present study.
Applicant's summary and conclusion
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