Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-894-2 | CAS number: 22288-43-3
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Expert Statement
- Adequacy of study:
- key study
- Reliability:
- other: Expert Statement
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- In order to fulfil the requirements for submission of a REACH dossier according to Annex IX of REACH Regulation (EC) No.1907/2006 (for substances >100 tones/year) and in absence of data on the toxicokinetics and dermal absorption, an assessment of toxicological behaviour is required. No studies are available on the toxicokinetics, metabolism and distribution of 1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate.
Data source
Materials and methods
Test material
- Reference substance name:
- 1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate
- EC Number:
- 244-894-2
- EC Name:
- 1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate
- Cas Number:
- 22288-43-3
- Molecular formula:
- C16H32O3
- IUPAC Name:
- 2,4,4-trimethylpentan-2-yl 2-ethylhexaneperoxoate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- While toxicokinetic data is not available on 1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate, if absorbed, it is expected to breakdown rapidly. There is no information on the actual breakdown products formed. 1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate is not expected to bioaccumulate.
- Executive summary:
The available physico-chemical and toxicological information of the substance has been evaluated and used to assess the toxicological behaviour. The results of this analysis will address the question on how the chemical will react in the body.
The ECHA “Guidance on information requirements and chemical safety assessment Chapter R.7c: Endpoint specific guidance May 2008” document provides guidance, which physico-chemical properties commonly determine oral, inhalatory and dermal absorption, distribution, metabolism and elimination of substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
