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EC number: 220-912-4 | CAS number: 2935-90-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- N/A to 1983-07-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted with methods similar to OECD 401. However, information on the test substance was lacking (i.e., purity).
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- Information on the test substance (i.e., purity) was lacking.
- Principles of method if other than guideline:
- N/A
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Methyl 3-mercaptopropionate
- EC Number:
- 220-912-4
- EC Name:
- Methyl 3-mercaptopropionate
- Cas Number:
- 2935-90-2
- Molecular formula:
- C4H8O2S
- IUPAC Name:
- methyl 3-sulfanylpropanoate
- Details on test material:
- - Name of test material (as cited in study report): methyl 3-mercaptopropionate
- Molecular formula (if other than submission substance): N/A
- Molecular weight (if other than submission substance): N/A
- Smiles notation (if other than submission substance): N/A
- InChl (if other than submission substance): N/A
- Structural formula attached as image file (if other than submission substance): N/A
- Substance type: active
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: N/A
- Age at study initiation: young adult
- Weight at study initiation: 203-288 g
- Fasting period before study: Animals were fasted 18 to 24 hours prior to dosing.
- Housing: Animals were housed two per cage.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (deg. C): Every attempt was made to maintain temperatures at 70+/-4 deg. F.
- Humidity (%): Every attempt was made to maintain a relative humidity of 40-60 %.
- Air changes (per hr): N/A
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: N/A To: N/A
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: N/A
- Amount of vehicle (if gavage): N/A
- Justification for choice of vehicle: N/A
- Lot/batch no. (if required): N/A
- Purity: N/A
MAXIMUM DOSE VOLUME APPLIED: Dosage volume for each rat was based on initial body weights.
DOSAGE PREPARATION (if unusual): N/A
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: N/A - Doses:
- 50, 100, 150, 250, 500 and 5000 mg/kg bw
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations performed on day of dosing (1, 2 and 4 hours) and twice daily thereafter. Observations included nature, onset, severity and duration of pharmacotoxic signs. Body weights were recorded at study initiation, day 7 and at termination (day 14).
- Necropsy of survivors performed: yes
- Other examinations performed: gross pathology - Statistics:
- LD50 calculations were estimated by the Behrens-Reed-Meunch method.
Results and discussion
- Preliminary study:
- N/A
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 206.4 mg/kg bw
- 95% CL:
- 149 - 285.9
- Remarks on result:
- other: See mortality section below.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 181.7 mg/kg bw
- 95% CL:
- 132.6 - 248.9
- Remarks on result:
- other: See mortality section below.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 193.6 mg/kg bw
- 95% CL:
- 154.2 - 243.2
- Remarks on result:
- other: See mortality section below.
- Mortality:
- Males:
No animals died in the groups exposed to 50-150 mg/kg of the test substance. 4 animals in the 250 mg/kg dose group died (within 2 hours of treatment) and all of the animals in the 500 and 5000 mg/kg dose groups died (within 1 hour of treatment).
Females:
One animal died (within 1 hour of treatment) in the 150 mg/kg dose group. All animals died (within 2 hours of treatment) in the dose groups of 250-5000 mg/kg. - Clinical signs:
- other: Clinical observations were noted among all rats during the study. All rats dosed at 50 mg/kg bw exhibited slight depression on Day 1 post-dose only. Clinical signs noted in animals of remaining dose levels included one or more of the following: depressi
- Gross pathology:
- There were no gross pathological findings noted in rats surviving to termination. Findings among the rats that were found dead included dark red lungs, test substance-like material in the stomach and/or intestines, and reddish fluid in the intestines.
- Other findings:
- - Organ weights: N/A
- Histopathology: N/A
- Potential target organs: N/A
- Other observations: N/A
Any other information on results incl. tables
N/A
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The acute oral LD50 in male and female rats was determined to be 193.6 mg/kg bw.
- Executive summary:
N/A
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