Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 431-230-3 | CAS number: 202483-62-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The skin sensitising potential of TS-2863 (2-(2-hexyl-decyloxy)-benzamide) was evaluated in a Guinea Pig Maximisation Test (GMPT) performed according to OECD 406 (Pels Rijcken, 1998). However, the test substance was applied with a semi-occlusive dressing. On day 1, ten animals were intradermally injected with a 5% concentration of the test substance. On day 8, 50% test substance was applied topically with a semi-occlusive dressing for 48 hours. On day 22, all the animals were challenged with 20% TS-2863 via topical application for 24 hours.
Slight to moderate erythema or necrosis was noted at most of the injection sites of 10/10 treated and 5/5 control animals 24 hours after intradermal induction, due to the injection and not to exposure to the test substance. No skin effects were observed in the treated or control group after the challenge. Under the conditions of this study, the test substance is not considered to be a skin sensitiser.
Migrated from Short description of key information:
Skin (OECD 406): not sensitising (Guinea pig maximisation test)
Justification for classification or non-classification
The available data on the skin sensitisation of the test substance do not meet the criteria for classification according to Regulation (EC) 1272/2008 or Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
