Registration Dossier
Registration Dossier
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EC number: 222-103-1 | CAS number: 3349-36-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The following data have been submitted to address the short-term toxicity to fish endpoint:
Steger-Hartmann T and Wendt B (1998). Acute toxicity of di-n-butyltin oxide (ZK 26385) to the Zebra fish, Danio rerio. Testing laboratory: Schering AG, Experimentelle Toxikologie, D-13342, Berlin Germany. Report no.: IC19. Owner company: Schering AG, Experimentelle Toxikologie, Berlin Germany. Study number: TXST19980196. Report date: 1998-12-11.
The key value for the chemical safety assessment is a LOEC (72h) of 3.1 mg/l taken from the Steger-Hartmann and Wendt (1998) study performed dibutyltin oxide.
Nagase, H., Hamasaki, T., Sato, T., Kito, H., Yoshioka, Y. and Ose, Y. (1991). Structure - activity relationships for organotin compounds on the red killifish 'Oryzlas latipes'. Applied Organometallic Chemistry 5: 91-97.
Result for DBTO: The short term LC50 is 0.839 mg/L.
The key study for this endpoint, Steger-Hartmann & Wendt (1998) was performed on dibutyltin oxide as the data available on dibutoxydibutylstannane is not sufficient for assessment.
Key value for chemical safety assessment
Additional information
Read-across between dibutyltin compounds to to dibutoxydibutylstannane concerning aquatic toxicity endpoints was considered appropriate as dibutyltin and octyltins are known to hydrolyse rapidly in water (as presented by Yoder 2003, under the data requirement hydrolysis), and form, in the case of dibutyltins, dibutyltin oxide.
- The key study, Steger-Hartmann and Wendt (1998) has been allocated a Klimisch score of 2, as it was used as read across from a supporting substance. The study was performed to the guideline OECD 203. Only one fish died during the course of the 72 hour study, when tested up to the saturation point. Only a 72 hour LOEC of 3.1 mg/L could be determined from the study.
The Nagase et al (1991) study was allocated a Klimisch score of 4 due to a lack of detail in the reporting of the methods and results. Only 48 hours LC50's were reported. This study is considered to be supporting studies. The 48 hr LC50 for di-n-butyltin oxide in the red killifish under semi-static conditions was 0.839 mg/L.
Key value for chemical safety assessment:
LC50 for freshwater fish >3.1 mg/L
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