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Diss Factsheets
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EC number: 209-090-8 | CAS number: 555-31-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
- Objective of study:
- absorption
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 417 (Toxicokinetics)
- Deviations:
- yes
- Remarks:
- 3 lapins males/dose
- GLP compliance:
- not specified
Test material
- Reference substance name:
- aluminium(3+) ion tris(propan-2-olate)
- Cas Number:
- 555-31-7
- Molecular formula:
- C₉H₂₁AlO₃
- IUPAC Name:
- aluminium(3+) ion tris(propan-2-olate)
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - lapins divisés en 4 groupes de 3 chacun
- poids initial de 2,0 - 2,6 kg
Administration / exposure
- Route of administration:
- other: inhalation et dermale
- Vehicle:
- water
- Details on exposure:
- Les lapins du groupe 3 ont été placés dans une chambre d'inhalation et une serviette imbibée d'alcool isopropylique à 70% a été appliquée sur la poitrine. Des serviettes imbibées d'alcool isopropylique ont ensuite été placées sur le plancher de la chambre d'inhalation pour assurer un environnement saturé.
- Duration and frequency of treatment / exposure:
- Étude de cinétique du sang: 4 heures
Étude de disposition: 4 heures
Doses / concentrations
- Remarks:
- Doses / Concentrations:
70% isopropyl alcohol
- No. of animals per sex per dose / concentration:
- 3 males/dose
- Control animals:
- no
- Details on dosing and sampling:
- Des échantillons de sang (3 ml) ont été prélevés immédiatement avant l'exposition à l'alcool, puis de nouveau à 1, 2, 3 et 4 heures. Tous les échantillons ont été dosés à l'aveugle pour les taux sanguins moyens d'alcool / acétone (mg / dl) par International Clinical Laboratories, Inc., St. Louis, MO, en utilisant une méthode GLC sur un Toxichron Bendex.
- Statistics:
- L'évaluation statistique de la différence des moyennes indépendantes a été réalisée en utilisant le test t de Student. Un niveau de P <0,05 était considéré comme significatif.
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parameters
- Key result
- Test no.:
- #1
- Toxicokinetic parameters:
- Cmax: Les niveaux d'alcool isopropylique sont passés de 0 à 112 mg / dl sur la période de 4 heures.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Les concentrations sanguines d'acétone ont augmenté régulièrement de 7 à 19 mg / dl au cours de la période de 4 heures.
Any other information on results incl. tables
Les élévations des taux sanguins d'isopropanol étaient hautement significatives (P <0,01) à tout moment.Seul le taux sanguin d'acétone de 4 heures était significativement différent (P <0,05) par rapport au départ.
Applicant's summary and conclusion
- Conclusions:
- Interprétation des résultats (information migrée): aucun potentiel de bioaccumulation basé sur les résultats de l'étude
- Executive summary:
Interprétation des résultats (information migrée): aucun potentiel de bioaccumulation basé sur les résultats de l'étude
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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