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Diss Factsheets
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EC number: 206-735-5 | CAS number: 371-40-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- other: QSAR toolbox
- Title:
- QSAR study for CAS: 371-40-4
- Year:
- 2 011
- Bibliographic source:
- OECD QSAR toolbox version 2.2, 2011:- Steven J. Broderius, Michael D. Kahl, Marilynn D. Hoglund; Use of joint toxic response to define the primary mode of toxic action for diverse industrial organic chemicals; Environ. Toxicol. Chem.14(9): 1591-1605,1995.
- Reference Type:
- review article or handbook
- Title:
- Reference ID: 15031
- Year:
- 2 012
- Bibliographic source:
- ECOTOX (ECOTOXicology database):- Steven J. Broderius, Michael D. Kahl, Marilynn D. Hoglund; Use of joint toxic response to define the primary mode of toxic action for diverse industrial organic chemicals; Environ. Toxicol. Chem.14(9): 1591-1605,1995.
- Reference Type:
- review article or handbook
- Title:
- Reaxys ID: 742030
- Year:
- 2 011
- Bibliographic source:
- Reaxys by Elsevier Properties SA; Broderius, Steven J.; Kahl, Michael D.; Hoglund, Marilynn D.; Environmental Toxicology and Chemistry; vol. 14; nb. 9; (1995); p. 1591 - 1606
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from OECD QSAR Toolbox and US EPA ECOTOX Database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-fluoroaniline
- EC Number:
- 206-735-5
- EC Name:
- 4-fluoroaniline
- Cas Number:
- 371-40-4
- Molecular formula:
- C6H6FN
- IUPAC Name:
- 4-fluoroaniline
- Details on test material:
- - Name of test material: 4-fluoroaniline
- Molecular formula: C6H6FN
- Molecular weight: 111.12
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- Age: 26-34 day(s)
Lifestage: JUVENILE
Study design
- Test type:
- flow-through
- Water media type:
- freshwater
- Total exposure duration:
- 4 d
Test conditions
- Hardness:
- 45 milligrams per liter Calcium ca
- Test temperature:
- 25 Celsius
- pH:
- 7.8
- Details on test conditions:
- Water alkalinity: 42 milligrams per liter Calcium ca
Results and discussion
Effect concentrations
- Duration:
- 4 d
- Dose descriptor:
- LC50
- Effect conc.:
- 23 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
- Conclusions:
- The LC50 value of 4-fluoroaniline to Fathead minnow during a 96hr flowthrough exposure is 16.9 mg/L and 23 mg/L
- Executive summary:
The LC50 value of 4-fluoroaniline to Fathead minnow during a 96hr flowthrough exposure is 16.9 mg/L and 23 mg/L. Though short term toxicity values to aquatic species indicate that the chemical could be classified for aquatic toxicity, but since 4-fluoroaniline is readily biodegradable in water and also is very water soluble and given the large dilution possibility in the aquatic environment, it is concluded that 4-fluoroaniline shall not exhibit toxicity to the aquatic organisms and the aquatic environment.
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