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Diss Factsheets
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EC number: 800-309-8 | CAS number: 231297-75-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Between 22 September and 5 October 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with agreed protocols, OECD Guidelines and to GLP standards, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Test material form:
- other: liquid
- Details on test material:
- Identification: Magnesdium sulfonate
Description: Clear, dark brown, viscous liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Young adult animals weighing 3209 to 3587 grams at initiation of dosing were identified by eartag and housed in individual suspended wire mesh cages. The animals were acclimated to laboratory conditions for a minimum of seven days prior to dosing. They were provided PMI Nutrition International, Inc Certified Rabbit LabDiet(R) 5322 feed (approx. 150g/day) during the study and Municipal water ad libitum. Environmental conditions were controlled: 68.2-69.1 deg F, 35.8 to 64.1 % humidity and 12 hours light/12 hour dark cycles.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 13 days
- Number of animals:
- 6
- Details on study design:
- A group of 6 animals were acclimated for a minimum of 7 days. A dose of 0.5 ml then was applied to a shaved, unabraded site on each animal. A semi-occlusive wrapping was applied to hold the test material in place. At the end of a 4 hours, the wrapping was removed and the site was wiped with a disposable towel moistened with deionized water to remove the test material. The test sites were then evaluated in accordance with the method of Draize at approximately 30-60 minutes, 24, 48 and 72 hours and daily through day 13 if irritation persisted. Animals were observed twice daily for mortality, and body weights were recorded at day 0 and termination.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- (intact skin)
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1.83
- Max. score:
- 4
- Reversibility:
- fully reversible within: day 13
- Irritation parameter:
- erythema score
- Remarks:
- (intact skin)
- Basis:
- mean
- Time point:
- other: 48 Hours
- Score:
- 1.67
- Max. score:
- 4
- Reversibility:
- fully reversible within: day 13
- Irritation parameter:
- erythema score
- Remarks:
- (intact skin)
- Basis:
- mean
- Time point:
- other: 72 Hours
- Score:
- 1.83
- Max. score:
- 4
- Reversibility:
- fully reversible within: day 13
- Irritation parameter:
- edema score
- Remarks:
- (intact skin)
- Basis:
- mean
- Time point:
- other: 24 Hours
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- edema score
- Remarks:
- (Initact skin)
- Basis:
- mean
- Time point:
- other: 48 Hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Remarks:
- (intact skin)
- Basis:
- mean
- Time point:
- other: 72 Hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Other effects:
- No mortality or effects on body weight were observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU-GHS
- Conclusions:
- In accordance with EU CLP Regulation (EC) No. 1272/2008 this substance is not classified as a skin irritant.
- Executive summary:
A study was undertaken in 1999 (Kerr, 1999) to investigate the skin irritation potential of Magnesium sulfonate (CAS 231297 -75 -9) in New Zealand White rabbits. A group of 6 animals were acclimated for a minimum of 7 days. A dose of 0.5 ml then was applied to a shaved, unabraded site on each animal using OECD Guideline 404. A semi-occlusive wrapping was applied to hold the test material in place. At the end of a 4 hours, the wrapping was removed and the site was wiped with a disposable towel moistened with deionized water to remove the test material. The test sites were then evaluated in accordance with the method of Draize at approximately 30-60 minutes, 24, 48 and 72 hours and daily through day 13 if irritation persisted. Animals were observed twice daily for mortality, and body weights were recorded at day 0 and at termination. Mean erythema scores at 24, 48 and 72 hours were 1.83, 1.67, and 1.83, respectively and were fully reversible by day 13. Mean oedema scores at 24, 48 and 72 hours were 0.17, 0, and 0, respectively and were fully reversible by 48 hours. No mortality or effects on body weight were observed. Based on the results of this study this substance is not classified as a skin irritant in accordance with EU CLP Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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