Registration Dossier
Registration Dossier
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EC number: 249-922-7 | CAS number: 29878-91-9
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP and Guidline Study. Deficiencies see below.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: DIN 38412 Teil 8
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,1'-binaphthyl-8,8'-dicarboxylic acid
- EC Number:
- 249-922-7
- EC Name:
- 1,1'-binaphthyl-8,8'-dicarboxylic acid
- Cas Number:
- 29878-91-9
- Molecular formula:
- C22H14O4
- IUPAC Name:
- [1,1'-binaphthalene]-8,8'-dicarboxylic acid
- Details on test material:
- The free acid is slightly soluble in water. To get a clear solution of the acid, the disodium salt of the substance was diluted in water at pH 10. Then the pH was adjusted to 7.7.
Constituent 1
Test solutions
- Details on test solutions:
- The free acid is slightly soluble in water. To get a clear solution of the acid, the disodium salt of the substance was diluted in water at pH 10. Then the pH was adjusted with HCl to 7.7 at 23°C.
Test organisms
- Test organisms (species):
- Pseudomonas putida
- Details on inoculum:
- Pseudomonas putida, DSM 50026.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 16 h
Test conditions
- Reference substance (positive control):
- yes
- Remarks:
- 2,4-Dichlorophenol at 30 and 70 mg/l
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 16 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 1 000 mg/L
- Duration:
- 16 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The substance is not toxic for the test organism. Under the test conditions 1,1´-binaphthyl-8,8´-dicharboxylic acid showed growth-promoting
properties.
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